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Abstract: TH-PO297

The Predictive Value of Neutrophil-to-Lymphocyte Ratio in Peritoneal Dialysis

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Authors

  • Marques, Roberto Calças, Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Carias, Eduarda C e, Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Domingos, Ana T., Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Guedes, Anabela M., Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Bernardo, Idalécio, Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Neves, Pedro Leao, Centro Hospitalar Universitário do Algarve, Faro, Portugal
Background

Neutrophil-to-lymphocyte ratio (NLR) may reflect a shift on immune response towards a pro-inflammatory pattern (i.e. high value of neutrophils) balanced with a depression of cell-mediated immunity (i.e. low values of lymphocytes). It has been used as prognostic factor in cardiovascular and oncologic diseases. In dialysis studies are scarce. The aim of this study was to evaluate NLR as a predictor of mortality in peritoneal dialysis (PD) patients.

Methods

In this longitudinal study, incident PD patients with a peritoneal equilibration test (PET) between 2004 and 2018 were included. Demographic, clinical and laboratory data were collected. Univariate and multivariate Cox regression analysis were performed to determine the association of NLR with survival.

Results

We included 122 PD patients (55.0 ± 17.5 years, 31,1% diabetic, Charlson Comorbidity Index (CCI): 5.0±2.5) with a mean follow-up of 30.2±24.0 months. Our population was dialysed with a mean Kt/V 2.75±0.94, and the mean evaluated parameters were: nGFR 6.7±4.7 ml/min/1.73m2, prealbumin 39.3±11.3 mg/dL, neutrophils 5.6±2.5x10^9/L, lymphocytes 1.8±2.3x10^9/L, NLR 3.99±2.6. Using the Cox model we found that higher CCI (HR=1.650, 95%CI 1.174-2.320), higher NLR (HR=1.662, 95%CI 1.117-2.472) and lower nGFR (HR: 0.706, 95%CI 0.554-0.900) were associated with higher mortality, when adjusted for nutritional status (n.s.).

Conclusion

In dialysis inflammation is associated with global cause mortality. The neutrophil-to-lymphocyte ratio is a simple calculation and it predicted survival in our PD patients.