Kidney Week

Abstract: SA-PO718

From Baseline Serum Creatinine to Creatinine-Based AKI: Different Definitions for Different Results

Session Information

• Pathology and Lab Medicine: Clinical
  November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Pathology and Lab Medicine

• 1602 Pathology and Lab Medicine: Clinical

Authors

• Samoni, Sara, IRRIV - San Bortolo Hospital, Vicenza, Italy

Sara Samoni,

• Lorenzin, Anna, IRRIV - San Bortolo Hospital, Vicenza, Italy

Anna Lorenzin,

• De Rosa, Silvia, IRRIV - San Bortolo Hospital, Vicenza, Italy

Silvia De Rosa,

• Marchionna, Nicola, IRRIV - San Bortolo Hospital, Vicenza, Italy

Nicola Marchionna,

• de Cal, Massimo, IRRIV - San Bortolo Hospital, Vicenza, Italy

Massimo de Cal,

• Bonilla, Luis Ignacio, IRRIV, Vicenza, Italy

Luis Ignacio Bonilla,

• Villa, Gianluca, University of Florence, Florence, Italy

Gianluca Villa,

• Zanella, Monica, San Bortolo Hospital, Vicenza, Italy

Monica Zanella,

• Brendolan, Alessandra, San Bortolo Hospital, Vicenza, Italy

Alessandra Brendolan,

• Ronco, Claudio, University of Padova, IRRIV, San Bortolo Hospital, Vicenza, Italy

Claudio Ronco,

Background

The lack of consensus on the definition of baseline serum creatinine(bsCr) influences the creatinine-based acute kidney injury(AKI) diagnosis, leading to problems relating to both research and clinical purpose. Pre-admission bsCr, measured in a time-period of a maximum of 365 days and minimum of 7 days from hospitalization, is considered the gold standard, but is rarely available in unscheduled patients. Our study aims at evaluating sensitivity and specificity of different bsCr.

Methods

We retrospectively enrolled patients admitted to our intensive care unit(ICU) over 6-month period. Inclusion criteria were:(i)availability of pre-admission bsCr;(ii)length of ICU stay≧72hrs.
According to the bsCr definitions derived from literature, we recorded:(i)sCr measured at ICU admission(admission bsCr);(ii)the lowest sCr achieved during the first 3 days of ICU stay(nadir bsCr);(iii)sCr calculated using the MDRD equation(back-estimation formula)(estimated bsCr), thus resulting 4 different bsCr for each patient. The occurrence of AKI was evaluated according to KDIGO criteria considering each of the 4 bsCr.

Results

Of 490 patients,195 had pre-admission bsCr. 14 patients were excluded because daily sCr was not available. Using pre-admission bsCr, we identified 79 patients who developed AKI(43.6%). Results are summarized in table 1.

Conclusion

Admission bsCr, frequently used in ICU, has the lowest sensitivity for AKI, missing almost entirely the diagnosis of community-acquired AKI. In previous studies, estimated bsCr has been demonstrated to overestimate the incidence of AKI in patients with pre-existent chronic kidney disease. In the absence of pre-admission bsCr, nadir bsCr seems to be the most accurate bsCr for diagnosis of AKI. Future efforts should focus on identifying a shared definition of bsCr.