Abstract: FR-PO176
Prevalence and Risk Factors of Vascular Calcification Among Chinese Patients with Early CKD
Session Information
- Bone and Mineral Metabolism: Phosphorus, FGF23, Vascular Calcification
November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Bone and Mineral Metabolism
- 402 Bone and Mineral Metabolism: Clinical
Authors
- Tang, Ying, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, GuangZhou, China
- Yu, Wenjuan, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, GuangZhou, China
- Chen, Junzhe, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, GuangZhou, China
- Ge, Shengnan, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, GuangZhou, China
- Fu, Sha, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, GuangZhou, China
Background
Extensive evidence suggests that vascular calcification(VC) independently predicts the risk of all-cause and CVD mortality. Here, we retrospectively studied the prevalence and risk factors of VC among Chinese patients with chronic kidney disease(CKD).
Methods
138 patients diagnosed with CKD in Sun Yat-sen Memorial Hospital were included for analysis. Abdominal aortic calcification (AAC), Coronary artery calcification (CAC) were assessed by plain lateral lumbar radiograph and multi-detector computed tomography (MDCT) respectively. The AAC score will be classified into three levels(0-5, 5-16 and ≥16) and the CAC score will be classified into four levels(0-100, 100-400, 400-1000 and ≥1000). Risk factors were analyzed using logistic regression.
Results
Among the 138 patients , 63 (45.7%) were diagnosed with early CKD(stage 1-3) who had an eGFR of 30 mL/min/1.73 m or greater. Of the 63 patients, 30 (47.6%) were found abdominal aortic calcification who had AAC score greater than 0; Specifically, level 1 accounted for 30.2%；level 2 for 17.5% and level 3 for 1.6%. The high prevalence rate of AAC among patients with CKD stage 1-3 is similar to stage 4-5(49.3%) but the latter is more severe on calcification degree. At the same time, we found that 41.1% patients of early CKD have coronary artery calcification while 52.8% patients of advanced CKD(stage 4-5). Both the prevalence rate and severity of CAC among patients with stage 4-5 are higher than stage 1-3. The multivariate logistic regression identified that older age [OR (95%CI) 1.131 (1.060, 1.206), P<0.001], DM [OR (95%CI) 6.523(1.490, 28.544), P=0.013] and increased SUA [OR (95%CI) 1.006(1.001, 1.011), P=0.028] were the risk factors of VC among Chinese patients with early CKD. However, except for age and DM, it was SBP [OR (95%CI) 1.037(1.005,1.070), P=0.022] but not the SUA(P=0.533) increased the risk of VC among patients with advanced CKD.
Conclusion
There is limited knowledge about the impact of VC on Chinese patients with CKD , causing poor prognosis and inadequate management. We were surprised to find such a high prevalence of VC in patients with early CKD. Now, we are conducting a multi-center, large sample prospective study (ChiCTR1900020925) for establishing a predictive model for VC in patients with chronic kidney disease(stage 1-3) and hope to help us prevent it more effectively.
Funding
- Government Support - Non-U.S.