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Abstract: TH-PO189

The Role of sCD146 in Assessing Hydration State of Hemodialysis Patients

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Dou, Yanna, Nephrology Hospital, the First Affiliated Hospital of Zhengzhou University, Henan,China, Zhengzhou, China
  • Xiao, Jing, Nephrology Hospital, the First Affiliated Hospital of Zhengzhou University, Henan,China, Zhengzhou, China
  • Zhao, Zhanzheng, Nephrology Hospital, the First Affiliated Hospital of Zhengzhou University, Henan,China, Zhengzhou, China
Background

sCD146 is a marker of endothelial cell injury and also a biomarker of systemic circulation congestion. There is no study on the relationship between sCD146 and water load hydration state in dialysis patients in Chinese dialysis patients. We will study the role of sCD146 and NT-proBNP in assessing hydration state in hemodialysis patients.

Methods

The maintenance hemodialysis patients of the First Affiliated Hospital of Zhengzhou University from September 2018 to January 2019 were screened. And 10 healthy people were enrolled to measure the level of sCD146 as control.
Clinical data were collecting, including sex, age, height, type of dialysis pathway, systolic blood pressure (sBP), hemoglobin (Hb), serum albumin (Alb), blood urea nitrogen (blood Urea Nitrogen, BUN), uric acid (UA), creatinine (Serum Creatinine), total cholesterol (TC) were collected. Triglycerid (TG), potassium, phosphorus, dialysis effectiveness index Kt/V, parathyroid Hormone (PTH). The blood was taken in the morning to measure the concentration of sCD146. Body weight was measured before and after dialysis on dialysis day, and bioelectrical impedance was measured by Xitro4200 bioelectrical impedance meter.Total body water (TBW), Extracellular Fluid Volume (ECV) and excess water (MEXF) were calculated. Ultrafiltration volume was recorded.

Results

Compared with 10 healthy controls, plasma sCD146 levels in hemodialysis patients increased before and after dialysis (275.58 [209.00, 370.80] VS. 187.03 [152.01, 214.09] ng/ml, P < 0.05), (233.00 [172.50, 442.59] VS. 187.03 [152.01, 214.09] ng/ml, P < 0.05).
Pearson or Spearman correlation analysis showed that sCD146 before dialysis was positively correlated with MEXF (r = 0.400, P < 0.05) before dialysis, negatively correlated with age (r = 0.394, P < 0.05), but not with pre-dialysis body weight (r = 0.030, P = 0.872), blood pressure (r =-0.085, P = 0.646), ECV/TBW (r = 0.269, P = 0.136).

Conclusion

sCD146 may be a new biomarker for the overhydration state in hemodialysis patients.

Funding

  • Government Support - Non-U.S.