Abstract: TH-PO706
Change and Clinical Significance of Serum IL-22 Concentration in Hypertensive Renal Damage Patients
Session Information
- Hypertension and CVD: Epidemiology, Risk Factors
November 07, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1403 Hypertension and CVD: Mechanisms
Authors
- Tang, Rong, Xiangya Hospital, Central South University, Changsha, China
- Meng, Ting, Xiangya Hospital, Central South University, Changsha, China
- Li, Xiaozhao, Xiangya Hospital, Central South University, Changsha, China
Background
CD4+T cells and their secreted cytokines contribute to the development of hypertensive renal damage. Our previous study showed that Th22 cells and its effect factor interleukin-22 (IL-22) increased significantly in Ang II-induced hypertensive renal damage mice, might play a promoting effects. However, the effects of Th22 and IL-22 in hypertensive patients remain unclear. This study is to explore change of serum IL-22 concentration and its correlation with other clinical indexes in patients with essential hypertension and hypertensive renal damage.
Methods
97 essential hypertension (EH) patients and 40 healthy control were enrolled in our study. The EH patients were divided into simple hypertension (SH) group (n=45) and hypertensive renal damage (HRD) group (n=52) according to 24h urinary protein (24h-UPRO) level. Basic clinical data were collected; serum IL-22, TNF-α and IL-6 levels were detected by ELISA; the proportion of Th22 cells in peripheral blood was evaluated by flow cytometry; IL-22 and IL-22 receptor (IL-22) expression in kidneys were determined by immunohistochemistry; serum high sensitivity C-reactive protein (hs-CRP) concentration was measured by immune turbidimetry. Correlation analysis was applied between serum IL-22 and other indexes.
Results
Serum IL-22 level and Th22 cells frequency in patients with hypertension were significantly higher than control participants. Compared with SH group, serum IL-22 level was elevated obviously in HRD group), and Th22 cells proportion was also higher in HRD group. Expression of IL-22 and IL-22R in kidneys were increased in hypertensive renal damage patients compared to control. Bivariate linear correlation analysis revealed that serum IL-22 level was positively correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), TNF-α，IL-6 and hsCRP; there was also a positive correlation between serum IL-22 concentration and Th22 cells proportion in hypertensive patients. Serum IL-22 level was positively correlated with 24h-UPRO level in HRD group.
Conclusion
Serum IL-22 and peripheral blood Th22 cells infiltration were significant increased in HRD group compared with SH group, serum IL-22 was closely correlated with extent of hypertensive renal damage, indicating that serum IL-22 may involved in the pathogenesis of hypertensive renal damage.
Funding
- Government Support - Non-U.S.