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Kidney Week

Abstract: FR-PO320

Role of Demographic Variables on Prevalence of Anxiety and Depression (AAD) in CKD Patients and Its Co-Relation with Quality of Life and CKD Outcome Parameters

Session Information

Category: CKD (Non-Dialysis)

  • 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Author

  • Sengupta, Pratim, Bellevue Clinic, Kolkata, India
Background

Adapting with AAD in presence of CKD is challenging. Being multifactorial addressing AAD needs better etiological understanding.The purpose of this study is to find the relationship between different riders of demography with AAD and to investigate whether AAD has any correlation with quality of life(QOL) or overall CKD outcome.

Methods

583 CKD patients (18-80yrs) of different stages and etiology,were enrolled in this prospective observational study.Any previous or ongoing treatment of psychiatric disorder,medical ailments or sorrowful events during recent past at the time of inclusion were excluded.The Hospital Anxiety and Depression Scale (HADS) were used as a tool to measure the AAD level.Demographic data,medical history,education level,professional details,nature composition and support from family,number of dependents,financial burden,and healthcare insurance coverage data were recorded.Baseline serum creatinine, estimated GFR(MDRD),routine clinical and lab data,QOL parameters ,hospitalization,cardiovascular events and mortality data were captured quarterly until the end of study.HADS was recorded every 3 months to assess the severity of AAD.All patients were longitudinally followed up for 5 years.SPSS v 25.0 was used for statistical analysis,p <0.05 were considered as statistically significant

Results

Out of 583 CKD patients [145(24.9%) dialysis and 438(75.1%) pre-dialysis], 59.3% were male and 40.6% were female.Mean age was 57.75 ±13.53 years.Anxiety was predominant in pre-dialysis patients whereas depression was prominent in dialysis subgroup.AAD were significantly more among male than female and in middle-aged than in elderly.Socioeconomic status, family support,dependent members in family and insurance coverage were variably associated with AAD.Maximum AS was observed while first encounter with nephrologist and when being advised for RRT. AS >8.0 and DS >7.0 was significantly correlated with poorer QOL parameters.Poorer blood pressure control,faster decline of GFR and frequent hospitalization were significantly correlated with AS >8.A positive trend toward association of all-cause mortality was observed with DS >7.

Conclusion

Different demographic variables has significant impact on AAD in CKD.AAD has variable impact on QOL, BP control,CKD progression and hospitalization or all-cause mortality.