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Abstract: FR-PO643

Granger Causality Analysis of Regulatory Network of Phosphate Metabolism in Healthy Individuals

Session Information

Category: Fluid and Electrolytes

  • 902 Fluid and Electrolytes: Clinical

Author

  • Ye, Guoxin, Division of Nephrology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Background

Basic and clinical studies reveal that the homeostasis of phosphate is maintained by a regulatory network. The aim of our study was to explore the variation of phosphatoninin with the change of diet.

Methods

6 healthy volunteers were treated with regular Pi diet (NPD) and high Pi diet (HPD) for 5 days. Their blood and urine specimens at 10 fixed time points on the 5th day of intervention were collected. In order to reveal the causality relationship in the phosphorus metabolism network, this study used the Granger causal analysis to determine time series relationship.

Results

HPD resulted in a significant increase in serum Pi and urinary Pi excretion. There was a significant increase in PTH. FGF23 was upward trend. By using Granger causal analysis, we found PTH was earliest change in RPD, which was the initiation factor. The change of FGF23 appeared at the latest that was the passive factor. In HPD, FGF23 was initiation factor. Serum Ca and Pi were passive factors.

Conclusion

With the traditional comparison, it was difficult to reveal the caucality relationship of phosphate network. By Granger causality analysis, we found in RPD kidney was the most significant organ in keeping serum Pi stably. In HPD, FGF23 was the main hormone to maintain homeostasis of phosphate regulatory network.