Abstract: FR-PO1172
Can Uric Acid Blood Levels in Renal Transplant Recipients Predict Allograft Outcome?
Session Information
- Transplantation: Clinical - Post-Transplant Complications
November 08, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 1902 Transplantation: Clinical
Authors
- Isakov, Ofer, Souraski Medical Center, Tel Aviv, Israel
- Schwartz, Doron, Souraski Medical Center, Tel Aviv, Israel
- Hod, Tamar, Souraski Medical Center, Tel Aviv, Israel
Background
Hyperuricemia is common after renal transplantation, especially in those receiving calcineurin inhibitors (CNI). Increased uric acid (UA) levels were found predictive of kidney disease and end-stage renal disease in those with normal renal function and disease progression in individuals with kidney disease. Little, however, is known about the relationship between UA levels and allograft outcome.
Methods
We conducted a retrospective single-center analysis (N=368) in order to assess UA blood levels posttransplant association with allograft outcome.
Results
Patients were divided into 2 groups based on the mean UA level measured between 1-12 months posttransplant. Those with mean UA level ≥ 7 and 6.5 mg/dL (N = 164) versus mean UA level< 7 and 6.5 mg/dL for men and women respectively (N=204) had lower GFR values at 1, 3 and 5 years posttransplant. In a multivariate analysis adjusted for age, gender, race, transplant type, mean CNI levels, presence of slow graft function (SGF) and baseline allograft function (GFR at 3 months posttransplant) the association of UA levels to allograft function were not significantly associated with differences in GFR at 1, 3 and 5 years posttransplant.
Conclusion
Hyperuricemia is a surrogate for a worse allograft function. After adjustment for baseline allograft function increased UA levels were not found to be an independent predictor of long-term allograft function despite the known association of hyperuricemia with progression of cardiovascular and renal disease.
Baseline Characteristics of the High versus low UA groups
High UA (N=164) | Low UA (N=204) | P Value | |
Age (years) | 52.24 (13.76) | 51.38 (13.92) | 0.553 |
Males | 84 (51.2) | 124 (60.8) | 0.083 |
Whites | 99 (60.4) | 134 (65.7) | 0.462 |
Blacks | 40 (24.4) | 38 (18.6) | |
LD | 70(42.7) | 138(67.6) | <0.001 |
DCD-ECD | 57(34.8) | 35(17.2) | |
SCD | 37(22.6) | 31(15.2) | |
SGF | 86 (52.4) | 61 (29.9) | <0.001 |
GFR 3M (ml/min) | 43.33 (15.06) | 58.37 (17.84) | <0.001 |
GFR 1Y (ml/min) | 45.92 (17.30) | 60.77 (19.70) | <0.001 |
GFR 3Y (ml/min) | 43.42 (20.64) | 58.02 (19.87) | <0.001 |
GFR 5Y (ml/min) | 41.81 (21.38) | 53.59 (23.12) | 0.009 |
Continuous variables are presented as means (and standard deviations), categorical variables are presented as number of patients (and % of the entire group).