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Kidney Week

Abstract: TH-PO088

Risk Factors of AKI in Patients with Decompensated Cirrhosis

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

  • Luo, Lianxin, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China
  • Zhou, Fangfang, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China
  • Han, Lina, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China
  • Luo, Qun, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China
Background

Acute kidney injury(AKI)is a common complication with high mortality and morbidity in decompensated cirrhotic patients.However, few studies concerning the risk factors of cirrhosis-associated AKI have been published. In our study, we aim to investigate the risk factors of AKI in patients with decompensated cirrhosis in our hospital from 2012 to 2016.

Methods

We performed a single-center retroperspective stuty. Clinical data of patients with decompensated cirrhosis were collected from Dept. of Liver diseases, Hwamei Hospital, University Of Chinese Academy of Sciences from 2012 to 2016. According to the KDIGO criteria, patients were divided into AKI group and non-AKI group . Risk factors for AKI were analyzed by univariate and multivariate analysis methods.

Results

945 inpatients with decompensated cirrhosis (mean age was 55.42 and 65.3% were male.) were enrolled, with the incidence of AKI being 17.7%. The mean course of cirrhosis was (5.59±4.94) years and the average length of stay was (20.01±14.00) days. Multivariate Logistic regression analysis showed that increased age (OR=1.031, p=0.001), infection (OR=7.125, p<0.001), decreasing eGFR (OR=0.845, p<0.001), ascites (OR=5.012, p<0.001), and ACEI/ARB use (OR=7.882, p=0.003) were independently correlated with patients with decompression cirrhosis complicated with AKI.

Conclusion

There was high incidence of AKI in patients with decompensated cirrhosis, whose independent risk factors were associated with increasing age, infection, decreasing eGFR, ascites and using of ACEI/ARB.

Funding

  • Government Support - Non-U.S.