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Abstract: TH-PO305

Prognostic Role of Platelet-to-Lymphocyte Ratio in Peritoneal Dialysis

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Authors

  • Marques, Roberto Calças, Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Domingos, Ana T., Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Carias, Eduarda C e, Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Guedes, Anabela M., Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Bernardo, Idalécio, Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Neves, Pedro Leao, Centro Hospitalar Universitário do Algarve, Faro, Portugal
Background

Platelet-to-lymphocyte ratio (PLR) has been introduced as useful inflammatory marker to predict the outcome for a wide spectrum of diseases such malignancies and cardiovascular pathologies. Since platelets are active players in inflammatory response, both thrombocytosis and high PLR are probably part of the same pathophysiological process. In dialysis studies are scarce. The aim of this study was to evaluate PLR as a predictor of mortality in peritoneal dialysis (PD) patients.

Methods

In this longitudinal study, incident PD patients with a peritoneal equilibration test (PET) between 2004 and 2018 were included. Demographic, clinical and laboratory data were collected. Univariate and multivariate Cox regression analysis were performed to determine the association of PLR with survival.

Results

We included 122 PD patients (55.0 ± 17.5 years, 31,1% diabetic, Charlson Comorbidity Index (CCI): 5.0±2.5) with a mean follow-up of 30.2±24.0 months. Our population was dialysed with a mean Kt/V 2.75±0.94, and the mean evaluated parameters were: nGFR 6.7±4.7 ml/min/1.73m2, prealbumin 39.3±11.3 mg/dL, platelet 269.6±86.5x10^9/L, lymphocytes 1.8±2.3x10^9/L, PLR 195.5±101.7. Using the Cox model we found that higher CCI (HR=1.827, 95%CI 1.284-2.600), higher PLR (HR=1.010, 95%CI 1.004-1.015) and lower nGFR (HR: 0.673, 95%CI 0.513-0.883) were associated with higher mortality, when adjusted for nutritional status (n.s.).

Conclusion

Inflammation is a known risk factor for global cause mortality in dialysis. In this study platelet-to-lymphocyte ratio, which is quite simple and cheap method, was validated as an inflammatory marker in PD patients.