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Abstract: SA-PO728

Podocytic Infolding Glomerulopathy: The Clinical Secrets of Hidden Disease

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Author

  • G, Anvesh, NIMS, Hyderabad, India
Background

Several cases of Podocytic infolding glomerulopathy (PIG) has been reported from Japan as a new disease entity since 2008. It is a rare glomerular abnormality seen predominantly among women in associaciation with membranous nephropathy and autoimmune diseases involving glomerular basement membrane (GBM) bubbling visualised by light microscopy (LM), invagination of the podocyte membrane, and the presence of microspheres viewable by electron microscopy (EM). The clinical features and pathogenesis of this condition are still unclear. We reviewed clinical, biochemical, and pathological features of cases of PIG at our institute.

Methods

We retrospectively analysed cases of PIG as per the diagnostic criteria during preceding two years.

Results

Seven cases of PIG have been reported from our institute. The mean age of the patients was 48, (43-65) years, and all were men. Both hypertension and diabetes were seen in five, one each had hypertension and diabetes. Four patients had nephrotic range proteinuria and two had insignificant proteinuria. All had increased creatinine with a mean of 4.3mg% . Autoimmune workup and viral markers were negative in all. LM showed diabetic nephropathy (DN) in 5 cases and hypertensive changes in 1 case and secondary FSGS in 1 case. Microspheres were present in all but podocyte infolding was present in 1 and cluster formation of microspheres was found in 3 cases

Conclusion

PIG in our case series differs from that of Japan in male preponderance and is associated with diabetic nephropathy. The clinical significance of PIG in south Indian population is yet to be elucidated.