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Abstract: TH-PO1054

Patterns and Trends of Infection Among Hospitalized Patients with Different Types of Chronic Glomerulonephritis: A Retrospective Study Spanning 18 Years from a Single Tertiary Hospital

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Fan, Xiaohong, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
  • Li, Hang, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
  • Li, Xuemei, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
  • Li, Xuewang, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
  • Cai, Jianfang, Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, BEIJING, China
Background

It remains unclear whether the patterns and trends of infection are differentials among different types of glomerulonephritis.

Methods

We conducted a retrospective analysis using the database of hospitalization with chronic glomerulonephritis in Peking Union Medical College Hospital (PUMCH), China from 2000 through 2017. The tenth revision from the International Classification of Diseases (ICD-10) codes of discharge diagnosis was used to identify infectious diseases and 6 kinds of glomerulonephritis including lupus nephritis (LN), systemic vasculitis (AAV), Henoch-Schönlein purpura nephritis (HSPN), IgA nephritis (IgAN), idiopathic membrane nephropathy(MN), and minimal change disease(MCD) . Cochran-Armitage trend test and Logistic regression were used for analysis.

Results

Between 2000 and 2017, there were 15,714 hospitalizations with aforementioned chronic glomerulonephritis. Their mean age was 51.7±19.8 years and 39.4% were males. The annual prevalence of overall infection increased steadily from 14.7% in 2000 to 33.0% in 2017 among all (p for trend <0.001). We found significant increasing trends of overall infection in LN, AAV, HSPN, IgAN, and MCD, but not in MN [Figure A]. Hospitalized patients with LN, AAV, and MN were more likely to have the infection as compared with those with IgAN (OR: 3.53, 95%CI 3.14-3.95, 3.92, 95%CI 3.30-4.64, and 1.36, 95%CI 1.17-1.57, respectively) after adjustment for age, gender, hypertension, and diabetes. The bacteria and virus infections were the top two infectious diseases, patients with LN, AAV, and MN also had a higher proportion of fungi infection [Figure B].

Conclusion

There had been an increasing trend of infection in hospitalized patients with chronic glomerulonephritis except for those with idiopathic membrane nephropathy. Prevalence of infection and infection patterns varied among hospitalized patients with different glomerulonephritis.