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Abstract: SU-OR45

Deceased Donor Families and Authorization for Research: Differences Among Ethnic Groups

Session Information

Category: Transplantation

  • 1902 Transplantation: Clinical

Authors

  • Goggins, Mariella Ortigosa, University of Miami School of Medicine, Miami, Florida, United States
  • Guerra, Giselle, University of Miami School of Medicine, Miami, Florida, United States

Group or Team Name

  • Miami Transplant Institute
Background

Research in transplantation requires next of kin(NOK) to authorize for participation in research. Aim was to determine the rate of research authorization by the NOK within different ethnic groups: African American(AA), White (W) or Hispanic(H).

Methods

Single center study of all deceased donor kidney transplants referred to our institution during 3/1/2019-10/31/2019 from multiple organ procurement organizations(OPO) across the United States. We looked at the authorization for donation form in DonorNet. We searched for the NOK research authorization agreement at the time of organ donation.Donors were grouped by self-identified ethnic groups as W, AA or H

Results

We had a total of 297 donors, yielding 401 kidney offers. 71% were imported from 46 different OPOs and 29% from our local OPO. Mean donor age (±SE) was 45.7±0.9. Donor ethnicity distribution was W 180 (60.6%); AA 66 (22.2%) and H 50 (16.8%). Overall 226 (76.1%) donors' NOK authorized for research and 71 (23.9%) declined research. Donor age <35yr had a lower rate of authorization 62.9% vs 81.3% and 80.6% for 35-49yr and>50yr respectively p=0.006. Table 1 shows ethnic distribution on rate of NOK authorization for research, which was significantly lower within AA donors 38/66 (57.6%).Logistic regression showed donor age<35yr and AA donor as more likely to decline research authorization, yielding multivariable p=0.0001 for AA donor and p=0.002 for younger donor age. Multivariable percentages who declined research authorization had highest rate among AA donors<35yr at 55%(11/20) compared to 37.0%(17/46) in AA donors>35yr; 31.0%(18/58) in W/H donors <35yr; and 14.5%(25/173) in W/H donors>35yr. Out of 401 donated kidneys, 93(23%) were not authorized to participate in research, of which 38/93(40.9%) were AA; 15/93(16.1%) were H and 40/93(43.1%) were W donors

Conclusion

In deceased donors from local and imported OPOs, the rate of declined authorization for research participation from NOK was higher among donors from AA ethnicity compared to donors from W or H backgrounds, especially when donor age is <35. Community education is crucial in the field.

Table 1: Rate of NOK Authorization for Research
Agree to ResearchW (n=181)AA (n=66)H (n=50)
yes n%152 (83.9%)38 (57.6%)36 (72%)
no n%29 (16.1%)*28 (42.4%)*14 (28%)*

p<0.0002 among 3 groups