Abstract: FR-OR12
Correlation Between Patient Activation and Quality of Life Among Patients with CKD
Session Information
- Clinical Trials and Related Studies to Improve CKD Outcomes
October 23, 2020 | Location: Simulive
Abstract Time: 05:00 PM - 07:00 PM
Category: CKD (Non-Dialysis)
- 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Dauleh, Mujahed Maher Issa, Penn State College of Medicine, Hershey, Pennsylvania, United States
- Ghahramani, Aria, Penn State College of Medicine, Hershey, Pennsylvania, United States
- Zebi, Ali Mohammed, Penn State College of Medicine, Hershey, Pennsylvania, United States
- Ghahramani, Nasrollah, Penn State College of Medicine, Hershey, Pennsylvania, United States
Background
Quality of Life (QOL) is an important outcome in patients with chronic kidney disease (CKD). We have previously demonstrated that online peer mentoring (PM) improves patient activation and QOL. In this study, we evaluate the correlation between patient activation and QOL among patients with CKD who received online PM.
Methods
We randomized 155 patients with stage 4 or stage 5 CKD to one of 3 groups: online PM, face-to-face (FTF) PM, or usual care. Participants in all 3 groups received a book that contained detailed information about kidney disease. Participants assigned to intervention groups received 6 months of PM, either FTF or through a secure online platform. At baseline and at 18 months, the participants completed the Patient Activation Measure® (PAM) and the Kidney Disease QOL-36 (KDQOL-36) instrument. We used linear mixed effect models to estimate the slope of change of PAM and subsets of KDQOL over time. We then calculated the correlation between PAM and individual subscales of KDQOL by Pearson’s Correlation Coefficient. We used SAS, version 9.4 (SAS Institute Inc., Cary, NC) for data analysis.
Results
Baseline KDQOL-36 and PAM scores, as well as demographic characteristics were similar among the 3 groups. Among the online PM group, there was a statistically significant improvement in:
1. The mean PAM score between baseline and 18 months (Slope estimate [SE]: 5.65; 95% confidence interval [CI]: 2.75, 8.52; P= 0.0001).
2. The following components of the KDQOL-36 score: Effects of Kidney Disease (EKD) (SE: 4.13; CI: 0.87, 7.4; P= 0.01); Burden of Kidney Disease (BKD) (SE: 5.44; CI: 1.24, 9.64; P= 0.01); Symptoms and Problems of Kidney Disease (SPKD) (SE: 6.00; CI: 3.09, 8.91; p= 0.006); SF-12 Physical Composite Score (PCS) (SE: 2.50; CI: 0.95, 4.06; P= 0.002); SF-12 Mental Composite Score (MCS) (SE: 3.46; CI: 1.78, 5.13; P<0.0001).
Among the online PM group, the improvement in PAM was correlated with improvements in 4 components of the KDQOL-36: EKD (Pearson Coefficient [PC]: 0.36; p=0.04); BKD (PC: 0.44; p=0.01); SPKD (PC: 0.47; p=0.005), PCS (PC: 0.35; p=0.04). There was no correlation between PAM and MCS.
Conclusion
Among CKD patients who receive online PM, there is a correlation between the improvements in PAM and KDQOL, suggesting that improved QOL may be a result of improved activation.
Funding: PCORI