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Abstract: TH-PO083

EPILAT-IRA Study: A Contribution to the Understanding of the Epidemiology of AKI in Latin America

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

  • Lombardi, Raul, Universidad de la República, Montevideo, Montevideo, Uruguay
  • Ferreiro, Alejandro, School of Medicine, Montevideo, Uruguay
  • Claure-Del Granado, Rolando, Hospital Obrero #2 - C.N.S.; Universidad Mayor de San Simon, School of Medicine, Cochabamba, Cercado, Bolivia, Plurinational State of
  • Rosa diez, Guillermo Javier, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
  • Burdmann, Emmanuel A., University of Sao Paulo Medical School, Sao Paulo, Brazil
  • Yu, Luis, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
  • Younes-Ibrahim, Mauricio, University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil

Group or Team Name

  • on behalf of EPILAT-IRA Study Group. AKI Committe Latin American Society of Nephrology and Hypertension
Background

Acute kidney injury (AKI) is a public health problem, due to its high and rising frequency, its association with increased morbidity and mortality, and the economical burden related to its care. Considering the limited data on AKI epidemiology in Latin America and the Caribbean, we performed a prospective observational study to determine risk factors, clinical profile, process of care and outcomes of AKI in the region

Methods

Participants were recruited by open invitation through the Latin American Society of Nephrology and Hypertension. Patients meeting the KDIGO AKI definition, during hospitalization, were included over a a 9-month period and designated as community or hospital acquired. De-identified clinical and lab data was entered in a specifically designed on-line platform. Co-variables potentially linked to AKI were recorded and correlated with mortality at hospital discharge and 90 days using a multiple logistic regression model

Results

A total of 57 participants from 15 countries provided data on 905 patients, the majority of them with acceptable coverage of basic needs. Median age was 64 (50-74) yrs. and 61% were male. Comorbidities were present in 77% of the patients. AKI was community-acquired in 62%. Dehydration, shock and nephrotoxic drugs were the most usual AKI causes. Seventy-seven percent of the patients were assessed by nephrologists. Renal replacement therapy was performed in 29% of cases. All-cause in-hospital mortality was 26.5% and was independently associated to older age, chronic liver disease, hypotension, shock and cardiac disturbance as etiologic factors, infection and sepsis as in-hospital complications, need of renal replacement therapy and mechanical ventilation. Mortality at 90-days follow up was 25%.

Conclusion

This study provides new information on the characteristics and outcomes of AKI patients in Latin America and Caribbean region. Notwithstanding, this study represents partially the AKI situation in the participant countries rather than the actual epidemiology of AKI in Latin America, a pending and needed task.