Abstract: SA-PO817
Dietary Fiber Intake Is Associated with Indoxyl Sulphate in Hemodialysis Patients
Session Information
- Health Maintenance, Nutrition, Metabolism - II
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1300 Health Maintenance, Nutrition, and Metabolism
Authors
- Mafra, Denise, Federal University Fluminense, Rio de Janeiro, RIO DE JANEIRO, Brazil
- Borges, Natalia Alvarenga, Federal University Fluminense, Rio de Janeiro, RIO DE JANEIRO, Brazil
- Nakao, Lia S., UFPR, Curitiba, Brazil
Group or Team Name
- Nutrição em Nefrologia
Background
Gut microbiota imbalance is a common complication in chronic kidney disease (CKD) patients. This dysbiosis is linked to increased gut-derived uremic toxins production such as indoxyl sulphate (IS), involved with inflammation and oxidative stress in these patients. Lifestyle modifications may have significant favorable effects on reduction of uremic toxins from the gut microbiota, as increased dietary fiber intake which seems to be associated with gut microbiota modulation and reduction on uremic toxins production. The aim of this study was to verify a possible relationship between fiber intake and IS plasma levels in hemodialysis (HD) patients.
Methods
In this cross-sectional study, 50 HD patients were evaluated. Indoxyl sulphate plasma levels were measured by Reversed-Phase High-Performance Liquid Chromatography (HPLC) and, the food intake was assessed using a 3-day 24-hour dietary recall.
Results
Table 1 shows the characteristics and food intake parameters of the HD patients evaluated. The IS plasma levels were negatively correlated with fiber intake (r = - 0.32, p = 0.02, Figure 1).
Conclusion
Our results suggest that increasing dietary fiber intake the IS plasma levels can be reduced in hemodialysis patients, probably due the gut microbiota modulation.
Table 1. Characteristics and food intake parameters of the HD patients.
| Parameters | Results |
| Age (years) | 54.1 ± 10.4 |
| BMI (kg/m2) | 26.2 ± 4.8 |
| Time on HD (months) | 47 (28 -78) |
| Kt/V | 1.4 ± 0.3 |
| Energy Intake (Kcal/Kg/day) | 19.0 ± 8.0 |
| Protein Intake (g/Kg/day) | 1.0 ± 0.3 |
| Fiber Intake (g/day) | 16.0 ± 7.6 |
| Indoxyl sulfate (mg/dL) | 28.0 ± 14.2 |
Funding
- Government Support - Non-U.S.