Abstract: SA-PO1162
Comparison of Clinical Outcomes Between High Anti-A/B Antibody Titer vs. Low Titer in ABO-Compatible Kidney Transplantation
Session Information
- Transplantation: Clinical - Rejection, Recurrent Disease, Incompatibility
November 09, 2019 | Location: Exhibit Hall, Walter E. Washington Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 1902 Transplantation: Clinical
Authors
- Lee, Jin ho, Bong Seng Memorial Hospital, Busan, Korea (the Republic of)
- Park, Yong ki, Dongnae Bong Seng Hospital, Busan, Korea (the Republic of)
- Kim, Donghan, Bongseng memorial hospital, Busan, Korea (the Republic of)
- Kim, Joong Kyung, Bong Seng Memorial Hospital, Busan, Korea (the Republic of)
- Oh, Joon Seok, Brigham and Women's Hospital, Chestnut Hill, United States
- Lee, Dongyeol, Bong Seng Memorial Hospital, Busan, Korea (the Republic of)
- Kim, Hee yeoun, Bong Seng Memorial Hospital, Busan, Korea (the Republic of)
- Sin, Yong hun, Bong Seng Hospital, Busan, Korea (the Republic of)
- Park, Woo Yeong, Dongsan Medical Center, Daegu, Korea (the Republic of)
Background
ABO incompatible(ABOi) kidney transplantation(KTP) reduces the waiting time of deceased donor KTP and extends the pool of living donor KTP. In recent data, ABOi KTP is known to have no significant difference in long term outcome compared to ABO compatible. However, high A/B antibody titer is still a challenge to overcome in ABOi KTP. In this study, high anti A/B antibody and low titer Ab were compared in ABOi KTP
Methods
We retrospectively evaluated 95 cases of ABOi KTP recipients from 2009 to 2018 in Bong Seng Memorial Hospital, BUSAN, South KOREA. High-titer isohaemagglutinin patients were defined by IgG anti A/B titres ≥1:256. There were 28 patients with high titer and 67 patients with low titer group. Primary outcome was patient survival and graft survival. The secondary outcome was bleeding tendency, biopsy proven rejection, plasmapheresis number, cost of treatment
Results
There was no statistical difference in the baseline characteristics between high and low titer group. Patient survival rate in the high titer group was not statistically significant compared to the low titer group. There was no significant difference in graft survival rate(Figure 1). There were no differences in complications such as bleeding tendency and number of blood transfusions. However, the anti-A / B antibody titer(49 ± 37 vs. 502 ± 384)(p=0.00) and the number of plasmapheresis(3.8 ± 1.7 vs. 7.2 ± 2.5)(p=0.00) were significantly lower in the low titer group. There was no difference in complications such as PTDM, angina, and myocardial infarction after transplantation. There were no significant differences in infection and rejection
Conclusion
High A/B antibody titer ABOi KTP showed no inferiority in clinical outcome compared to low titer. The authors suggested that the high Anti A/B antibody titer lower the medical alert thresholds from contraindication to high risk