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Abstract: TH-PO303

Effects of Initial Hypoalbuminemia on the Longitudinal Changes of Residual Renal Function and Peritoneal Membrane in Incident Peritoneal Dialysis Patients: A Single-Center, Long-Term Follow-Up Study

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Authors

  • Rhee, Harin, Pusan National University Hospital, Busan, Korea (the Republic of)
  • Jeong, Hyeyun, Pusan National University Hospital, Busan, Korea (the Republic of)
  • Han, Miyeun, Pusan National University Hospital, Busan, Korea (the Republic of)
  • Kim, Il Young, Pusan National University Yangsan Hospital, Yangsan, Korea (the Republic of)
  • Song, Sang Heon, Pusan National University Hospital, Busan, Korea (the Republic of)
  • Seong, Eun Young, Pusan National University Hospital, Busan, Korea (the Republic of)
  • Lee, Dong Won, Pusan National University School of Medicine, Yangsan, Korea (the Republic of)
  • Lee, Soo Bong, Pusan National University Yangsan Hospital, Yangsan, Korea (the Republic of)
Background

Hypoalbuminemia was reported closely associated with increased patients’ mortality and technical failure rate in PD patients. However, there were little studies that compared longitudinal changes of residual renal function or peritoneal membrane function according to the serum albumin level.

Methods

We retrospectively included patients who started PD between January 2010 and December 2015. We divided patients into two groups according to the initial serum albumin level. Hypoalbuminemia was defined as the serum albumin level lower than 3.5 g/dL. To compare longitudinal changes of residual renal function and peritoneal membrane status between two groups, we repeatedly collected data for urine output, uKt/V, peritoneal ultrafiltration, pKt/V, 4hr DPcr ratio per 1 year. We also checked technical failure rate and all-cause mortality rate of them.

Results

A total of 153 patients were included and 36.6% of them had hypoalbuminemia. During the median follow up period of 42.5 months, 9.8% of the patients were dead, 30.3% of the patients received kidney transplantation and the other 30.3% of the patients changed modality to hemodialysis. All-cause mortality rate was significantly higher in the hypoalbuminemia group (log rank 0.001). In both groups, residual renal function showed decreasing trend, peritoneal UF and pKt/V showed increasing trend and their changing rates were more rapid in hypoalbuminemia group (Figure 1).

Conclusion

Initial hypoalbuminemia was associated with rapid decline of residual renal function and increased all-cause mortality rate in incident PD patients. Thus, patients with hypoalbuminemia needed to be closely monitored.