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Abstract: FR-PO954

Longitudinal Impacts of Bariatric Surgery on Renal Function in CKD

Session Information

Category: CKD (Non-Dialysis)

  • 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention


  • Madapoosi, Siddharth S., University of Michigan, Ann Arbor, Michigan, United States
  • Mariani, Laura H., University of Michigan, Ann Arbor, Michigan, United States

Prior studies of obesity show improved renal function after bariatric surgery. This study examines renal function over 10 years pre- and post-bariatric surgery among patients with a reduced baseline eGFR, including patients with CKD.


Retrospective cohorts of patients with CKD and/or who underwent bariatric surgery prior to 11/30/22 were identified from the Michigan Medicine EHR using ICD-10 and CPT codes. Multivariable piecewise linear mixed models were fit on eGFR (2021 CKD-EPI), adjusting for age, gender, race, ethnicity, BMI, hypertension, diabetes, and surgery type or CKD stage. Pre- and post-surgery eGFR trajectories were compared in patients with a baseline eGFR<90. eGFR trajectories were then compared between CKD patients post-surgery and either propensity score-matched non-CKD patients post-surgery or CKD patients who did not undergo surgery.


Patients with baseline eGFR<90 (n=688) had a slower annual rate of eGFR decline [95% CI] post vs. pre-surgery (-1.85 [-1.97,-1.72] vs. -3.22 [-3.41,-3.02] mL/min/1.73m2; p<0.001). Following surgery, CKD patients (n=139) had a slower annual rate of eGFR decline compared to 278 matched non-CKD patients (-1.28 [-1.87,-0.69] vs. -2.62 [-2.83,-2.41] mL/min/1.73m2; p<0.001). Annual eGFR decline was also slower among CKD patients who underwent surgery compared to 278 matched CKD patients who did not (-0.20 [-0.83,0.43] vs. -1.11 [-1.37,-0.85] mL/min/1.73m2; p<0.001).


Bariatric surgery is associated with a slower rate of eGFR decline in patients with a reduced baseline eGFR, including CKD patients. Future modeling of proteinuria may support these findings and identify if the faster eGFR decline in healthy patients correlates to a decrease in glomerular hyperfiltration after surgery.

Predicted values of eGFR (95% CI) from adjusted linear mixed models of (a) patients with baseline eGFR<90, (b) bariatric surgery patients with/without CKD, and (c) CKD patients with/without bariatric surgery


  • Other NIH Support