Abstract: TH-PO1013
Prevalence and Risk Factors for CKD and CKDu in León, Nicaragua
Session Information
- CKD Epidemiology, Risk Factors, Prevention - I
November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Strasma, Anna, Duke University School of Medicine, Durham, North Carolina, United States
- Mejía, Ángel Fernando, Microbiology Research Institute, National Autonomous University of Honduras, Tegucigalpa, Honduras
- Aragon, Aurora, WUQU’ KAWOQ, Maya Health Alliance, Tecpán, Guatemala
- López, Indiana Mercedes, WUQU’ KAWOQ, Maya Health Alliance, Tecpán, Guatemala
- Park, Lawrence, Duke Global Health Institute, Durham, North Carolina, United States
- Hogan, Susan L., The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, United States
- Thielman, Nathan M., Duke Global Health Institute, Durham, North Carolina, United States
- Wyatt, Christina M., Duke University School of Medicine, Durham, North Carolina, United States
- Gonzalez, Marvin Antonio, University College London Research Department of Renal Medicine, London, United Kingdom
Background
CKD of unknown etiology (CKDu) disproportionately affects young people in Central America who lack traditional CKD risk factors (diabetes and hypertension) and is instead linked to heat stress, occupational and environmental exposures, nephrotoxic medications, and/or genetic conditions. This study aimed to estimate the prevalence of CKD and to identify risk factors for traditional CKD and CKDu in Nicaragua.
Methods
Surveys and assessment for CKD markers in urine and serum were performed in 15-59 year olds in households of the León municipality of Nicaragua. The survey included questions on demographics, health behaviors, occupation, and medical history. Participants with CKD were subdivided into traditional CKD and suspected CKDu based on history of diabetes, hypertension, or other specified conditions. A multinomial logistic regression model was used to identify factors associated with traditional CKD and CKDu, compared to the non-CKD reference group.
Results
In 1795 study participants, CKD prevalence was 8.6%. Prevalence in males was 2-fold higher than females (12% vs 6%). Of those with CKD, 30% had suspected CKDu. Both traditional CKD and CKDu were associated with male sex and increasing age. Traditional CKD was associated with a family history of CKD and lower socioeconomic status, while CKDu was associated with non-treated water sources and a lower body mass index.
Conclusion
Both traditional CKD and CKDu are significant burdens in this region. Our study supports previous hypotheses of CKDu etiology and emphasizes the importance of CKD screening.
Odds ratios and 95% confidence intervals from a multinomial logistic regression model for CKD from traditional risk factors and suspected CKDu compared to the non-CKD reference group.