Abstract: SA-PO838
The Protein/Creatinine Ratio Is a Reliable Indicator of 24-Hour Urine Protein, Regardless of the Level of Renal Function in Patients with Glomerulopathies
Session Information
- Glomerular Diseases: From Inflammation to Fibrosis - III
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1401 Glomerular Diseases: From Inflammation to Fibrosis
Authors
- Gutierrez Peredo, Gabriel Brayan, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Bahia, Brazil
- Montaño-Castellon, Iris, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Bahia, Brazil
- Gutierrez-Peredo, Andrea Jimena, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Bahia, Brazil
- Lopes, Antonio Alberto, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Bahia, Brazil
Group or Team Name
- TUNARI Study.
Background
We aimed to determine the accuracy of the urine isolated protein/creatinine ratio (PCR) test, against the gold standard 24-hour urine protein (24hUP) measurement in patients with glomerulopathies, and according to the levels of renal function.
Methods
This prospective study of patients with glomerulopathies was developed at Professor Edgard Santos University Hospital in Salvador, Bahia-Brazil. The PCR and 24hUP measurements were performed using conventional methods within a maximum interval of 24 hours between the measurements. The patients were classified into three groups according to their renal function, group 1= <30 ml/min/1.73m2, group 2= 30-60 ml/min/1.73m2 and group 3= >60 ml/min/1.73m2. Spearman correlation coefficient (rs) and ROC curves were employed to compare PCR with 24hUP.
Results
The total was 167 urinary samples from 134 patients. The mean age was 42 ± 16 yrs, 68% were female and 91% non-white. A good correlation was observed between PCR and 24hUP total sample (rs= 0.7, p= <0.000), as well as in comparison with the different levels of renal function (rs= 0.8 for group 1, rs= 0.9 for group 2 and rs= 0.8 for group 3). The ROC between PCR and 24hUP total sample yield an AUC of 0.94 (CI= 0.89, 0.97), high sensitivity of 91% and specificity of 83%, at the optimal cut-off point was 0.7. The groups representing three levels of renal function showed high sensitivity and specificity in comparisons of both methods (group 1= 82%, 100%, group 2= 97%, 89% and group 3= 88%, 92%) with an AUC of 0.92, 0.96 and 0.96, respectively.
Conclusion
PCR shows high sensitivity and specificity for monitoring patients with glomerulopathies compared to 24hUP. Our findings suggest that PCR is a useful parameter to evaluate and monitor patients with different glomerulopathies regardless of the level of renal function.
Results in the total sample and by degree of renal function comparing protein/creatinine ratio with 24-hour urine protein
| Variables | Total N=167 | Spearman Correlation | Cut-off by Youden Index | Sensitivity (%) | Specificity (%) | Area under ROC curve (95%CI) |
| PCR vs 24hUP total sample | 167 | 0.8 | 0.7 | 91 | 83 | 0.94 (0.8;0.9) |
| Degree of kidney function | ||||||
| <30 ml/min/1,73 m2 | 35 | 0.7 | 0.8 | 82 | 100 | 0.92 (0.8;0.9) |
| 30-60 ml/min/1,73 m2 | 42 | 0.8 | 0.9 | 97 | 89 | 0.96 (0.9;1.0) |
| >60 ml/min/1,73 m2 | 90 | 0.8 | 0.8 | 88 | 92 | 0.96 (0.9;1.0) |