Abstract: SA-PO951
Cnm-Positive Streptococcus mutans, a Major Pathogen of Dental Caries, May Cause IgA Nephropathy via Tonsils
Session Information
- Glomerular Diseases: Translational Studies and Biomarkers
November 04, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Trials
Authors
- Misaki, Taro, Division of Nephrology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan
- Naka, Shuhei, Okayama Daigaku, Okayama, Okayama, Japan
- Nagasawa, Yasuyuki, Hyogo Ika Daigaku, Nishinomiya, Hyogo, Japan
- Matsuoka, Daiki, Okayama Daigaku, Okayama, Okayama, Japan
- Ito, Seigo, Japan Self-Defense Iruma Hospital, Iruma, Japan
- Matayoshi, Saaya, Osaka Daigaku, Suita, Osaka, Japan
- Nomura, Ryota, Hiroshima Daigaku, Higashihiroshima, Hiroshima, Japan
- Matsumoto-Nakano, Michiyo, Okayama Daigaku, Okayama, Okayama, Japan
- Nakano, Kazuhiko, Osaka Daigaku, Suita, Osaka, Japan
Background
The presence of Streptococcus mutans, a major pathogen of dental caries, expressing Cnm protein encoded by cnm in the oral cavity has been associated with the pathogenesis of IgA nephropathy (IgAN). Although tonsillectomy is applied for the treatment of IgAN, its effectiveness in the patients harboring cnm-positive S. mutans in the oral cavity is not clear.
This study aimed to investigate the effects of tonsillectomy on patients with IgAN who harbor cnm-positive S. mutans in the oral cavity.
Methods
The presence of cnm-positive S. mutans was analysed by polymerase chain reaction in saliva specimens from 117 patients with IgAN. The patient's history of tonsillectomy was examined, and they were divided into four groups based on the results of cnm-positive S. mutans detection and tonsillectomy history: group A (n=52) (tonsillectomy (-), cnm-positive S. mutans (-)); group B (n=35) (tonsillectomy (+), cnm-positive S. mutans (-)); group C (n=16) (tonsillectomy (-), cnm-positive S. mutans (+)), and group D (n=14) (tonsillectomy (+), cnm-positive S. mutans (+)). The subjects’ clinical parameters were analysed.
Results
The proportion of patients with an estimated glomerular filtration rate <60 mL/min was significantly higher in group C than the other groups (p < 0.0083). The proportion of proteinuria 2+ or higher was significantly higher in group C than the other groups (p < 0.0083). In the cnm-positive S. mutans (+) groups, serum IgA was significantly lower in tonsillectomy group than in non-tonsillectomy group (266.9mg/dl vs 358.9mg/dl, p < 0.05).
Conclusion
These results suggest that the exacerbation of IgAN by cnm-positive S. mutans may be mediated by the tonsils and tonsillectomy may be effective in patients with IgAN who harbor cnm-positive S. mutans in the oral cavity.