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Abstract: SA-PO952

Porphyromonas gingivalis Infection in Oral Cavity Is Associated with Elevated Galactose-Deficient IgA1 in IgA Nephropathy

Session Information

Category: Glomerular Diseases

  • 1402 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Misaki, Taro, Seirei Hamamatsu Byoin, Hamamatsu, Shizuoka, Japan
  • Ito, Seigo, Japan Self-Defense Iruma Hospital, Iruma, Japan
  • Naka, Shuhei, Okayama Daigaku, Okayama, Okayama, Japan
  • Nagasawa, Yasuyuki, Hyogo Ika Daigaku, Nishinomiya, Hyogo, Japan
  • Matsuoka, Daiki, Okayama Daigaku, Okayama, Okayama, Japan
  • Matayoshi, Saaya, Osaka Daigaku, Suita, Osaka, Japan
  • Nomura, Ryota, Hiroshima Daigaku, Higashihiroshima, Hiroshima, Japan
  • Matsumoto-Nakano, Michiyo, Okayama Daigaku, Okayama, Okayama, Japan
  • Nakano, Kazuhiko, Osaka Daigaku, Suita, Osaka, Japan
Background

The association between Porphyromonas gingivalis, a major periodontal bacteria, and the pathogenesis of IgA nephropathy (IgAN), with a focus on galactose-deficient IgA1 (Gd-IgA1), has not been fully understood.

Methods

Saliva samples were obtained from 30 IgAN patients and 44 patients with chronic kidney disease (CKD) to analyze the presence of P. gingivalis using PCR with a specific set of primers. The association between P. gingivalis detection and clinical parameters, including plasma Gd-IgA1, was analyzed for each group.

Results

IgAN group showed a significantly higher serum Gd-IgA1 level than CKD group (p < 0.05). P. gingivalis-positive group had a significantly higher serum Gd-IgA1 level than P. gingivalis-negative group in IgAN and CKD patients (p < 0.05). P. gingivalis-positive group in IgAN patients also showed a significantly higher serum Gd-IgA1 level than P. gingivalis-negative group in IgAN patients (p < 0.05). As for kidney biopsy findings, P. gingivalis-positive group exhibited a significantly higher frequency of the existence of segmental glomerulosclerosis than P. gingivalis-negative group when evaluating by the Oxford classification of IgAN (p < 0.05).

Conclusion

Our results suggest that P. gingivalis presence in oral cavity may be associated with IgAN pathogenesis due to induction of elevated level of Gd-IgA1.