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Abstract: SA-PO564

Effect of Dialysis Treatment on Structural Brain Connectivity in Patients with ESRD

Session Information

Category: Dialysis

  • 801 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Choi, Byeongo, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Kim, Yang Wook, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Oh, Yeongrok, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Yi, Jiyae, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Park, Bongsoo, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Park, Sihyung, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Lee, Yoo jin, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Heo, Changmin, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
Background

End-stage renal disease (ESRD) patients are known to have reduced structural and functional brain connectivity associated with cognitive function. However, the effect of dialysis treatment on brain connectivity is not understood. This study was designed to evaluate effects of dialysis treatment on structural brain connectivity in patients with ESRD.

Methods

This prospective study was conducted with 20 ESRD patients with pre-dialysis and 35 healthy controls. The patients underwent T2-weighted and three dimensional T1-weighted magnetic resonance imaging (MRI) before and 3 months after dialysis initiation, and cortical thickness was calculated. We applied a graph theoretical analysis for calculating the structural co-variance network based on the cortical thickness. We compared the cortical thickness and structural co-variance network between ESRD patients with pre-dialysis and healthy controls, and between ESRD patients with pre-dialysis and those with post-dialysis.

Results

The mean cortical thickness in both hemispheres was lower in ESRD patients with pre-dialysis than in healthy controls (2.296 vs. 2.354, p=0.030; 2.282 vs. 2.362, p=0.004; respectively), and it was higher in ESRD patients with post-dialysis than in those with pre-dialysis (2.333 vs. 2.296, p=0.001; 2.322 vs. 2.282, p=0.002; respectively). In analysis of the structural co-variance network, the assortative coefficient was lower in ESRD patients with pre-dialysis than that in healthy controls (-0.062 vs. -0.031, p=0.029), and it was higher in ESRD patients with post-dialysis than those with pre-dialysis (-0.002 vs. -0.062, p=0.042).

Conclusion

We found that there were differences in cortical thickness and structural co-variance network before and after dialysis in ESRD patients. This indicates that dialysis treatment affects structural brain connectivity and will contribute to understand the pathophysiologic mechanism of cognitive function alterations resulting from dialysis treatment in ESRD patients.