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Abstract: SA-PO551

Intrinsic Prefrontal Functional Connectivity According to Cognitive Impairment in Patients with ESRD

Session Information

Category: Dialysis

  • 801 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Oh, Yeongrok, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Park, Bongsoo, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Kim, Yang Wook, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Park, Sihyung, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Lee, Yoo jin, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Heo, Changmin, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Yi, Jiyae, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
  • Choi, Byeongo, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of)
Background

This study aimed to investigate differences in intrinsic prefrontal functional connectivity according to the presence of cognitive impairment in patients with end-stage renal disease (ESRD) using functional near-infrared spectroscopy (fNIRS).

Methods

We prospectively enrolled 37 patients with ESRD who were undergoing hemodialysis for more than six months and had no previous history of neurological or psychiatric disorders. The NIRSIT Lite device was used to acquire fNIRS data, and the NIRSIT Lite Analysis Tool program was used to process the data and generate a functional connectivity matrix. We obtained functional connectivity measures by applying graph theory using BRAPH program from the connectivity matrix using the BRAPH program. All patients with ESRD underwent a Korean version of the Montreal Cognitive Assessment (MoCA-K) to assess their cognitive function.

Results

Of the 37 patients with ESRD, 23 had cognitive impairment, whereas 14 patients showed no cognitive impairment. Intrinsic prefrontal functional connectivity was significantly different between groups. The network measures of the strength, global efficiency, and mean clustering coefficient were lower (4.458 vs. 5.129, p=0.018; 0.397 vs. 0.437, p=0.028; 0.316 vs. 0.421, p=0.003; respectively) in ESRD patients with cognitive impairment than those without cognitive impairment. There were no significant correlations between MoCA-K scores and clinical characteristics.

Conclusion

We demonstrated a significant association between cognitive function and intrinsic prefrontal functional connectivity in patients with ESRD. ESRD patients with cognitive impairment have reduced connectivity and segregation in the prefrontal brain network compared with those without cognitive impairment.