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Abstract: SA-PO530

Association of Serum Magnesium with Atrial Fibrillation in Patients Requiring Peritoneal Dialysis

Session Information

Category: Hypertension and CVD

  • 1602 Hypertension and CVD: Clinical

Authors

  • Nakata, Kenji, Toho Daigaku Iryo Center Ohashi Byoin, Meguro-ku, Tokyo, Japan
  • Toida, Tatsunori, Kyushu Hoken Fukushi Daigaku, Nobeoka, Miyazaki, Japan
  • Kurita, Noriaki, Fukushima Kenritsu Ika Daigaku Igakubu Daigakuin Igaku Senko, Fukushima, Japan
  • Joki, Nobuhiko, Toho Daigaku Iryo Center Ohashi Byoin, Meguro-ku, Tokyo, Japan
Background

It has been known that morbidity of atrial fibrillation (AF) in chronic kidney disease is higher than in general population. Age, obesity, diabetes mellitus (DM), and cardiovascular disease, these are thought to be one of the risk factors of AF. Hypomagnesemia is also potential risk factor of AF in hemodialysis patients, while it has not been studied in peritoneal dialysis (PD) patients. Hence, we examined association between of serum magnesium (sMg, mg/dL) with AF.

Methods

A nation-wide, cross-sectional study was performed by using data from Japanese Renal Data Registry, which encompasses a nationwide population dialysis centers, corrected at the end of 2019. The inclusion criteria were as follows: only PD patients, aged≥20. The exclusion criteria were as follows: missing data for Mg and history of AF. Among 332599 dialysis patients, 2366 PD patients were enrolled into this study finally. They were divided three groups according to the lower and upper level of sMg general reference value of 1.8 and 2.6, named low-, normal-, and high-sMg group respectively. Odds ratio (OR) for AF was calculated in each group compared with normal-sMg group by logistic regression analysis. AF was diagnosed by rest 12-leads electrocardiogram.

Results

Mean age was 63±13 years, 65.1% of them were male, 47.8% had DM. Mean sMg level was 2.14±0.58, and 4.3% had AF. In unadjusted model, the odds for AF was significantly increasing in low-sMg group compared with normal-sMg group (OR 2.23, p=0.0003), while high-sMg group did not show significant increment or decrement of OR for AF. After adjusting of confounding variables of age, sex, DM, and current smoker, same trend had seen between low and norml sMg groups.

Conclusion

Hypomagnesemia was closely associated with AF in PD patients. Preventing hypomagnesemia may reduce the incidence of AF in PD patients. We may need to monitor the sMg level regularly and pay attention more to hypomagnesemia to prevent AF in PD patients.

Odds ratio for AF in three groups divided by sMg
 Model 1Model 2Model 3
 OR95%CIpOR95%CIpOR95%CIp
Mg, mg/dL         
1.8<2.231.44-3.460.00032.121.36-3.300.00082.051.30-3.220.0018
1.8-2.61  1  1  
2.6<0.930.47-1.850.850.990.49-1.960.980.970.47-2.000.94

Adjusted factor: Model 1; unadjusted. Model 2; age, sex. Model 3; age, sex, diabetes mellitus, current smoker