Abstract: FR-PO831
Cigarette Smoking and Prevalent Kidney Stone: The National Health and Nutrition Examination Survey 2011-2018
Session Information
- Health Maintenance, Nutrition, Metabolism - II
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Tang, Jie, Brown University Warren Alpert Medical School, Providence, Rhode Island, United States
- Chonchol, Michel, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
- Raker, Christina A., Brown University Warren Alpert Medical School, Providence, Rhode Island, United States
- Sammartino, Cara, Johnson & Wales University, Providence, Rhode Island, United States
Background
Cigarette smoking (CS) may affect the risk of kidney stone (KS) disease because it has been linked to an increased bone loss. In addition, major trace elements found in cigarette can also promote KS formation. Here, we aimed to examine the independent association between CS and prevalent KS disease defined as self-reports of any previous episode of kidney stone.
Methods
We examined The Third National Health and Nutrition Examination Survey (NHANES) 2011-2018, a large US population-based cross-sectional study, and used logistic regression analyses to determine the independent association between CS and prevalent KS disease.
Results
19,405 participants were included for analysis, 1,895 had KS disease. 19% of stone formers (SF) versus 18% of non-stone formers (NSF) were active smokers (p<0.001), and average daily cigarettes smoked were 14 among SF vs. 12 among NSF (p= 0.02). Mean serum cotinine (a major metabolite of nicotine) concentration (SCC) was 64 ng/ml among SF vs. 54 ng/ml among NSF (p=0.01). Active CS associated strongly with an increased odds of KS disease in regression analysis after adjustment for demographics, BMI, histories of hypertension, diabetes, dyslipidemia and cardiovascular disease, alcohol intake, and dietary sodium, potassium and water intakes, odds ratio (OR)=1.30, 95% confidence interval (CI)=1.05-1.50, p=0.02 (Table 1). Higher SCC also associated significantly with an increased odds of KS disease when SCC was modeled as a continuous variable (OR=1.0007, 95% CI: 1.00-1.01, p=0.003), or when comparing highest tertile of SCC to lowest tertile (OR =1.30, 95% CI: 1.10–1.50, p=0.001)(Table 1). No major interactions were found in the final regression analyses.
Conclusion
Our study showed CS had a strong independent association with an increased risk of KS disease. Future prospective studies are needed to clarify the causal relationship between CS and KS formation.
Funding
- Private Foundation Support