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Kidney Week

Abstract: TH-PO850

Outcomes of Living Related Kidney Donors in a Tertiary Care Kidney and Liver Transplant Facility of a Developing Country

Session Information

Category: Transplantation

  • 2102 Transplantation: Clinical

Authors

  • Ijaz, Maria, Pakistan Kidney and Liver Institute & Research Center, Lahore, Punjab, Pakistan
  • Afroz, Tahreem, Pakistan Kidney and Liver Institute & Research Center, Lahore, Punjab, Pakistan
  • Ahmad, Hafiz Ijaz, Pakistan Kidney and Liver Institute & Research Center, Lahore, Punjab, Pakistan
  • Manzoor, Adil, Pakistan Kidney and Liver Institute & Research Center, Lahore, Punjab, Pakistan
  • Awais, Muhammad, University Hospital Kerry, Tralee, Kerry, Ireland
  • Bokhari, Syed Rizwan A., University of Rochester Medical Center, Rochester, New York, United States
Background

The long-term effects of unilateral nephrectomy for the live kidney donors are a neglected area of study in the developing countries. In Western countries like US, there is extensive data on living donor outcome through National Health and Nutrition Examination Survey (NHANES III), while no such resource is available in Pakistan.
The purpose of this study is to evaluate the outcome of kidney donors at a large public sector Academic hospital, Pakistan Kidney and Liver Institute, Lahore.

Methods

One hundred and thirty-two successive donors with living donor nephrectomies (during March 2018 to Feb 2021) were enrolled in this prospective observational study. Off these,100 donors were successfully followed up once every six months for total of six encounters in 3 years. Outcome included short and intermediate term effects of unilateral nephrectomy on donor physical parameters (blood pressure and BMI), kidney function (serum creatinine, eGFR) and glycaemic status (HbA1c) by comparing pre and post donation data. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation.

Results

Out of 100 living donors followed, 51 were male. All donors were in age range of 18-69 years with mean age 30-49 years. Left donor nephrectomy was performed in 89 (89%) patients. Mean diastolic blood pressure was slightly decreased and mean HbA1C pre and post donation were not statistically significant. Mean eGFR value before nephrectomy was 106.1ml/min and it dropped by 38% (65.2 ml/min) at 6 months. The eGFR then increased by 12% at 1year, 10% at 1.5 years, 16% at 2 years, 14% at 2.5 years and 18% (79.3ml/min) at 3 years post nephrectomy.

Conclusion

We hereby conclude that living kidney donation resulted in initial decline in the renal function because of loss of one kidney. Subsequently, taking post-donation value of eGFR at 6 months as baseline, it gradually increased by 18% at 3 years.