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Abstract: FR-PO952

Physical Activity Is an Independent Predictor of CKD Development Among Healthy Individuals

Session Information

Category: CKD (Non-Dialysis)

  • 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention


  • Beckerman, Pazit, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel
  • Erman, Orit, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel
  • Tiosano, Shmuel, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel
  • Qasim, Husam, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel

The cardiovascular and metabolic benefits of physical activity has been discussed in length, however, the association between physical fitness and progression to kidney disease is lacking. We aimed to identify the association between cardiorespiratory fitness and development of chronic kidney disease (CKD) among healthy population.


We investigated 11,579 healthy self-referred subjects who underwent annual medical screening. All subjects had an eGFR above 60 ml/min/1.73m2, no known kidney disease, hematuria or proteinuria, and were free of diabetes or cardiovascular disease at baseline. All participants completed a maximal exercise test, and were categorized into low and high cardiorespiratory fitness groups based on age- and gender-specific quintiles. The primary end point was the development of CKD defined as eGFR below 45 ml/min/1.73m2 during follow-up.


Median follow-up was 7.6 years, and the median participants' age was 50±8years. Baseline creatinine and eGFR were 1.02 mg/dl and 81 ml/min/1.73m2, respectively. During follow-up, 81 (0.6%) participants developed CKD, the cumulative probability significantly higher among the low fitness group (HR=2.41, p=0.001). The effect of physical fitness on the risk to develop CKD remained significant after adjusting for age, gender, baseline creatinine and other cardiovascular risk factors.


Cardiorespiratory fitness is an independently risk factor inversely associated with development of significant CKD.