Kidney Week

Abstract: FR-PO808

Aerobic Exercise Capacity and Kidney Function Decline in Heart Failure with Preserved Ejection Fraction Patients

Session Information

• Health Maintenance, Nutrition, Metabolism - II
  November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1500 Health Maintenance, Nutrition, and Metabolism

Authors

• Kim, Jae Young, National Health Insurance Service Ilsan Hospital, Goyang, Gyeonggi-do, Korea (the Republic of)

Jae Young Kim,

• Yoon, Minjae, Seoul National University Bundang Hospital, Seongnam, Korea (the Republic of)

Minjae Yoon,

• Han, Seung Hyeok, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of)

Seung Hyeok Han,

• Yoo, Tae-Hyun, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of)

Tae-Hyun Yoo,

• Kang, Shin-Wook, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of)

Shin-Wook Kang,

• Park, Jung Tak, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of)

Jung Tak Park,

Background

Chronic kidney disease (CKD) is a complication frequently found in HFpEF patients and results in poor prognosis. However, factors related with increased risk of kidney function decline in HFpEF are not well known.

Methods

Among a total of 424 HFpEF patients with estimated glomerular filtration rate (eGFR) >60 mL/min/1.73 m², aerobic exercise function was assessed by the peak O2 consumption (VO_2peak) values obtained through cardiopulmonary exercise test. Primary outcome was development of incident CKD, defined as two consecutive eGFR of <60 ml/min/1.73 m² separated by ≥90 days.

Results

The mean age of patients was 64.2 ± 10.6 years and 33.5% were male. Cardiac ejection fraction and eGFR at baseline were 67.0 ± 6.8 % and 87.5 ± 12.2 mL/min/1.73 m², respectively. During 1082.8 person-years of follow-up, CKD incidence rate gradually increased in patients with lower VO_2peak levels. Multivariable Cox analyses revealed that 1-standard deviation increase in the VO_2peak level was associated with a 33% lower risk of CKD development. The adjusted HR (95% CI) of the lowest VO_2peak tertile group was 3.07 (1.51-6.24) when compared to the highest tertile group.

Conclusion

Poor aerobic exercise capacity, represented by reduced VO_2peak levels, is closely related with a higher risk of CKD development among HFpEF patients.