ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on X

Kidney Week

Abstract: FR-PO1110

Risk Factors for COVID-19-Related Hospitalization After Reinfection in Maintenance Dialysis Patients

Session Information

  • COVID-19 - II
    November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Coronavirus (COVID-19)

  • 000 Coronavirus (COVID-19)

Authors

  • Shieu, Monica, Dialysis Clinic Inc, Nashville, Tennessee, United States
  • Manley, Harold, Dialysis Clinic Inc, Nashville, Tennessee, United States
  • Li, Nien Chen, Dialysis Clinic Inc, Nashville, Tennessee, United States
  • Harford, Antonia, Dialysis Clinic Inc, Nashville, Tennessee, United States
  • Hsu, Caroline M., Tufts Medical Center, Boston, Massachusetts, United States
  • Miskulin, Dana, Tufts Medical Center, Boston, Massachusetts, United States
  • Weiner, Daniel E., Tufts Medical Center, Boston, Massachusetts, United States
  • Johnson, Doug, Dialysis Clinic Inc, Nashville, Tennessee, United States
  • Lacson, Eduardo K., Dialysis Clinic Inc, Nashville, Tennessee, United States
Background

SARS-CoV-2 reinfection is a common occurrence. However, risk factors for COVID-19-related hospitalization with COVID-19 recurrences among maintenance dialysis patients are uncertain.

Methods

All adult maintenance dialysis patients at Dialysis Clinic, Inc. with 1) at least two COVID-19 diagnoses between 2/1/2020 and 1/31/2023 and 2) the second diagnosis was after 2/1/2021 (when vaccine became available) were included. SARS-CoV-2 reinfection was defined by a positive test >90 days after the first positive test. SARS-CoV-2-related hospitalization (within 30 days) of a recurrent infection were defined by a documented primary diagnosis for the episode of care of COVID-19. Stepwise logistic regression models were used to identify risk factors for COVID-19 hospitalization after reinfection. Exposure time accounting for time since last vaccination and prior COVID-19 infection was weighted for all models.

Results

Of 610 patients with ≥2 COVID-19 infections included in the analysis, 99 (16.2%) patients were hospitalized after COVID-19 reinfection. 410 were not hospitalized, 165 were hospitalized once, and 35 were hospitalized twice. Unvaccinated status, older age, usage of immune-modulating medications, transplant history, smoking history, comorbidities, low serum albumin, anemia, and vascular catheter usage were associated with increased risk for COVID-19 hospitalization after reinfection. There was a dose-response relation between higher vaccine number and lower risk of hospitalization (p for trend=0.02).

Conclusion

Hospitalization risk for COVID-19 reinfection remained high (16.2%). Despite prior infection, unvaccinated patients had higher risk. Traditional risk factors such as age, diabetes, low serum albumin, and catheter usage remained significant.

COVID-19 Hospitalization after Reinfection