Abstract: FR-PO1110
Risk Factors for COVID-19-Related Hospitalization After Reinfection in Maintenance Dialysis Patients
Session Information
- COVID-19 - II
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Coronavirus (COVID-19)
- 000 Coronavirus (COVID-19)
Authors
- Shieu, Monica, Dialysis Clinic Inc, Nashville, Tennessee, United States
- Manley, Harold, Dialysis Clinic Inc, Nashville, Tennessee, United States
- Li, Nien Chen, Dialysis Clinic Inc, Nashville, Tennessee, United States
- Harford, Antonia, Dialysis Clinic Inc, Nashville, Tennessee, United States
- Hsu, Caroline M., Tufts Medical Center, Boston, Massachusetts, United States
- Miskulin, Dana, Tufts Medical Center, Boston, Massachusetts, United States
- Weiner, Daniel E., Tufts Medical Center, Boston, Massachusetts, United States
- Johnson, Doug, Dialysis Clinic Inc, Nashville, Tennessee, United States
- Lacson, Eduardo K., Dialysis Clinic Inc, Nashville, Tennessee, United States
Background
SARS-CoV-2 reinfection is a common occurrence. However, risk factors for COVID-19-related hospitalization with COVID-19 recurrences among maintenance dialysis patients are uncertain.
Methods
All adult maintenance dialysis patients at Dialysis Clinic, Inc. with 1) at least two COVID-19 diagnoses between 2/1/2020 and 1/31/2023 and 2) the second diagnosis was after 2/1/2021 (when vaccine became available) were included. SARS-CoV-2 reinfection was defined by a positive test >90 days after the first positive test. SARS-CoV-2-related hospitalization (within 30 days) of a recurrent infection were defined by a documented primary diagnosis for the episode of care of COVID-19. Stepwise logistic regression models were used to identify risk factors for COVID-19 hospitalization after reinfection. Exposure time accounting for time since last vaccination and prior COVID-19 infection was weighted for all models.
Results
Of 610 patients with ≥2 COVID-19 infections included in the analysis, 99 (16.2%) patients were hospitalized after COVID-19 reinfection. 410 were not hospitalized, 165 were hospitalized once, and 35 were hospitalized twice. Unvaccinated status, older age, usage of immune-modulating medications, transplant history, smoking history, comorbidities, low serum albumin, anemia, and vascular catheter usage were associated with increased risk for COVID-19 hospitalization after reinfection. There was a dose-response relation between higher vaccine number and lower risk of hospitalization (p for trend=0.02).
Conclusion
Hospitalization risk for COVID-19 reinfection remained high (16.2%). Despite prior infection, unvaccinated patients had higher risk. Traditional risk factors such as age, diabetes, low serum albumin, and catheter usage remained significant.
COVID-19 Hospitalization after Reinfection