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Abstract: TH-PO230

Cardiovascular Health and CKD Progression Among US Hispanic/Latino Adults of the Hispanic Community Health Study/Study of Latinos, 2008-2017

Session Information

Category: Hypertension and CVD

  • 1602 Hypertension and CVD: Clinical


  • Chakrabarti, Amit Kumar, University of Miami School of Medicine, Miami, Florida, United States
  • Inker, Lesley Ann, Tufts Medical Center, Boston, Massachusetts, United States
  • Drexler, Yelena, University of Miami School of Medicine, Miami, Florida, United States
  • Swift, Samuel L., University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States
  • Lash, James P., University of Illinois Chicago College of Medicine, Chicago, Illinois, United States
  • Daviglus, Martha L., University of Illinois Chicago, Chicago, Illinois, United States
  • Pirzada, Amber, University of Illinois Chicago, Chicago, Illinois, United States
  • Sotres-Alvarez, Daniela, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
  • Johns, Tanya S., Albert Einstein College of Medicine, Bronx, New York, United States
  • Elfassy, Tali, University of Miami School of Medicine, Miami, Florida, United States

The primary cause of death in chronic kidney disease (CKD) is cardiovascular (CV) disease. “Life’s Essential 8” (LE8) is an established measure of CV health. Our objective was to examine the relationship between CV health (LE8) and CKD progression among US Hispanic/Latino adults, an understudied but growing population.


The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a longitudinal cohort of Hispanic/Latino adults 18-74 years old from four US cities, examined at visit 1 (V1) (2008-2011) and V2 (2014-2017). At V1, participants underwent a comprehensive assessment of health behaviors (diet, smoking status, physical activity, sleep duration) and clinical measurements (body mass index, blood pressure, cholesterol, fasting glucose, medication use) used to estimate a LE8 score (range: 0 to 100). Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine and cystatin C using the 2021 CKD-Epi equation and albumin to creatinine ratio (ACR) was measured from urine. CKD was defined as eGFR < 60 ml/min/1.73m2 or ACR ≥ 30mg/g. Change in eGFR and log ACR were defined as the difference in each measure between V1 and V2. To estimate the association between LE8 score with change in eGFR and log ACR, we used linear regression models adjusted for follow-up time, demographic, socio-economic, and clinical factors. All analyses accounted for HCHS/SOL complex survey design.


Among 1,284 Hispanic/Latino participants with CKD at V1, mean age was 48.6, 57.2% were women, and mean LE8 was 61.1 (SE: 0.7). Over an average of six years of follow-up, eGFR declined by 5.8 ml/min/1.73m2 and log ACR declined by 0.60. From multivariable adjusted models, for each 10-unit increment (improvement) in LE8 score, eGFR declined by 0.99 less (95% CI: -1.97, -.02) and log ACR declined an additional 0.15 (95% CI: 0.06, 0.28) between V1 and V2.


Among diverse US Hispanics/Latino adults with CKD, greater LE8 score (better CV health) was associated with modest but statistically significantly lower declines in eGFR and greater improvements in log ACR over six years.


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