Kidney Week

Abstract: TH-PO230

Cardiovascular Health and CKD Progression Among US Hispanic/Latino Adults of the Hispanic Community Health Study/Study of Latinos, 2008-2017

Session Information

• Hypertension and CVD: Clinical - I
  November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1602 Hypertension and CVD: Clinical

Authors

• Chakrabarti, Amit Kumar, University of Miami School of Medicine, Miami, Florida, United States

Amit Kumar Chakrabarti,

• Inker, Lesley Ann, Tufts Medical Center, Boston, Massachusetts, United States

Lesley Ann Inker,

• Drexler, Yelena, University of Miami School of Medicine, Miami, Florida, United States

Yelena Drexler,

• Swift, Samuel L., University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States

Samuel L. Swift,

• Lash, James P., University of Illinois Chicago College of Medicine, Chicago, Illinois, United States

James P. Lash,

• Daviglus, Martha L., University of Illinois Chicago, Chicago, Illinois, United States

Martha L. Daviglus,

• Pirzada, Amber, University of Illinois Chicago, Chicago, Illinois, United States

Amber Pirzada,

• Sotres-Alvarez, Daniela, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Daniela Sotres-Alvarez,

• Johns, Tanya S., Albert Einstein College of Medicine, Bronx, New York, United States

Tanya S. Johns,

• Elfassy, Tali, University of Miami School of Medicine, Miami, Florida, United States

Tali Elfassy,

Background

The primary cause of death in chronic kidney disease (CKD) is cardiovascular (CV) disease. “Life’s Essential 8” (LE8) is an established measure of CV health. Our objective was to examine the relationship between CV health (LE8) and CKD progression among US Hispanic/Latino adults, an understudied but growing population.

Methods

The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a longitudinal cohort of Hispanic/Latino adults 18-74 years old from four US cities, examined at visit 1 (V1) (2008-2011) and V2 (2014-2017). At V1, participants underwent a comprehensive assessment of health behaviors (diet, smoking status, physical activity, sleep duration) and clinical measurements (body mass index, blood pressure, cholesterol, fasting glucose, medication use) used to estimate a LE8 score (range: 0 to 100). Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine and cystatin C using the 2021 CKD-Epi equation and albumin to creatinine ratio (ACR) was measured from urine. CKD was defined as eGFR < 60 ml/min/1.73m² or ACR ≥ 30mg/g. Change in eGFR and log ACR were defined as the difference in each measure between V1 and V2. To estimate the association between LE8 score with change in eGFR and log ACR, we used linear regression models adjusted for follow-up time, demographic, socio-economic, and clinical factors. All analyses accounted for HCHS/SOL complex survey design.

Results

Among 1,284 Hispanic/Latino participants with CKD at V1, mean age was 48.6, 57.2% were women, and mean LE8 was 61.1 (SE: 0.7). Over an average of six years of follow-up, eGFR declined by 5.8 ml/min/1.73m² and log ACR declined by 0.60. From multivariable adjusted models, for each 10-unit increment (improvement) in LE8 score, eGFR declined by 0.99 less (95% CI: -1.97, -.02) and log ACR declined an additional 0.15 (95% CI: 0.06, 0.28) between V1 and V2.

Conclusion

Among diverse US Hispanics/Latino adults with CKD, greater LE8 score (better CV health) was associated with modest but statistically significantly lower declines in eGFR and greater improvements in log ACR over six years.

Funding

• NIDDK Support