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Kidney Week

Abstract: TH-PO590

Adverse Educational Outcomes in Glomerular Disease

Session Information

Category: Glomerular Diseases

  • 1402 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Garrity, Kelly, University of California Los Angeles, Los Angeles, California, United States
  • Putnam, Nathaniel, University of Michigan Michigan Medicine, Ann Arbor, Michigan, United States
  • Salmon, Eloise, University of Michigan Michigan Medicine, Ann Arbor, Michigan, United States
  • Massengill, Susan F., Atrium Health, Charlotte, North Carolina, United States
  • Kamil, Elaine S., Cedars-Sinai Medical Center, Los Angeles, California, United States
  • Khalid, Myda, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Isaac, Jaya, Montefiore Health System, Bronx, New York, United States
  • Richardson, Kelsey L., Oregon Health & Science University, Portland, Oregon, United States
Background

Research on kidney disease’s cognitive impacts in youth has largely focused on CAKUT patients due to the extent of brain development in the first 5 years of life. Our prior research found decreased high school diploma/GED attainment in those with adolescent Glomerular Disease (GD) onset. However, school impacts range beyond diploma attainment. No studies have analyzed the likelihood of patients with renal disease onset solely after age 5 reporting any adverse educational impact. Objective: Determine the prevalence of any educational impact on GD patients diagnosed between ages 5-19 and which factors might contribute.

Methods

CureGN prospective cohort study participants with Minimal Change Disease(MCD), Focal Segmental Glomerulosclerosis(FSGS), Membranous Nephropathy(MN), or IgA Nephropathy(IgAN) diagnosed between ages 5-19(n= 817) were included in the analysis, with the outcome defined as any self reported educational impact. Odds ratios(OR) based on General Estimating Equations were used to determine predictors of educational impact. Predictors of interest included race-ethnicity, child (5-12) vs adolescents (13-19) GD onset, parental education, adherence, APOL1 high risk allele, disease type, sex, and number of coexisting conditions.

Results

43%(348/817) reported GD ever impacted their education. Table 1 shows OR of the educational impact of predictors.

Conclusion

GD impacts a high percent of patients’ educations, even with onset after age 5. Having coexisting conditions and Black race(reference White) increased the likelihood while IgAN(reference MCD) decreased the likelihood of reporting an educational impact. The racial disparity in educational outcomes and the underlying causes of GD's adverse educational outcomes warrant more research.