Abstract: FR-PO826
Depressive Symptoms Are Associated with Increased Hospitalization Rate in CKD Patients: A Systematic Review and Meta-Analysis of Cohort Studies
Session Information
- Health Maintenance, Nutrition, Metabolism - II
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Leesutipornchai, Thiratest, University of Hawai'i at Manoa John A Burns School of Medicine, Honolulu, Hawaii, United States
- Arayangkool, Chinnawat, University of Hawai'i at Manoa John A Burns School of Medicine, Honolulu, Hawaii, United States
- Tanariyakul, Manasawee, University of Hawai'i at Manoa John A Burns School of Medicine, Honolulu, Hawaii, United States
- Aiumtrakul, Noppawit, University of Hawai'i at Manoa John A Burns School of Medicine, Honolulu, Hawaii, United States
Background
Depressive symptoms are relatively common in patients with chronic kidney disease (CKD). Recent studies showed that depressive disorders are associated with increased mortality risk in patients with CKD. However, evidence regarding the impact of depression on the risk of hospitalization in the CKD population is still limited. Therefore, we performed a systematic review and meta-analysis to explore the association between depressive symptoms and the risk of hospitalization in CKD patients.
Methods
We comprehensively searched MEDLINE, EMBASE and Cochrane Library from inception to October 2022. Included studies were cohort studies assessing the association of depressive symptoms on hospitalization rate among CKD patients, using the random-effects to calculate risk ratios (RR) and 95% confidence intervals (CIs).
Results
Six cohort studies were included in the analysis with a total of 11,258 CKD patients (7,404 patients with depressive symptoms and 4,122 patients without depressive symptoms). Subjects with depressive symptoms had an increased risk of hospitalization (pooled RR 1.139, 95% CI: 1.055–1.229, p = 0.001, I2 = 51.1%) compared to those without depressive symptoms. In subgroup analysis, depressive symptoms were associated with an increased risk of hospitalization in both CKD patients who were not receiving dialysis (pooled RR 1.432, 95% CI: 1.204-1.704, P = <0.001, I2 = 0.0%) and CKD patients who were receiving dialysis (pooled RR 1.088, 95% CI: 1.057-1.119, P = <0.001, I2 = 0.0%).
Conclusion
Our meta-analysis demonstrated that depressive symptoms were associated with an increased risk of hospitalization. This possible association is essential given the implication of depression screening to improve the quality of life in CKD patients.