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Abstract: SA-PO588

The Association Between Adipokines and Cardiovascular (CV) Risk Factors in Hemodialysis Patients

Session Information

Category: Dialysis

  • 801 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Khan, Sarwar, The University of Texas Southwestern Medical Center, Dallas, Texas, United States
  • Van Buren, Peter N., The University of Texas Southwestern Medical Center, Dallas, Texas, United States
Background

Non-traditional risk factors in cardiovascular (CV) disease among hemodialysis (HD) patients include mineral bone disease and extracellular volume overload. Adiponectin is an adopokine that has an inverse relationship with CV disease in the general population, but studies in HD patients show conflicting results regarding its association with CV morbidity and mortality. We explored associations between adiponectin and leptin with various CV risk factors in a subset of an HD cohort.

Methods

We conducted a cross-sectional study of hypertensive HD patients. We measured adiponectin and leptin with ELISA from frozen plasma obtained in a midweek treatment. BP was measured per HD protocol. And we obtained pre and post HD measurements of ECV with bioimpedance spectroscopy. We conducted Pearson correlation and multiple linear regression analysis to determine associations between adipokines and other clinical variables.

Results

There were 24 participants who had adiponectin levels (mean 12238 [504] ng/mL) with 58% men, 58% Black, and 50% with diabetes. There were no differences in adiponectin based on sex, race or diabetes. Adiponectin correlated negatively with fat free mass (r=-0.51, p=.02) and dry weight (r=-0.44, p=.03). Leptin correlated positively with fat mass (r=0.7, p=.004) and dry weight (r=0.6, p=.003), but had a negative correlation with ECV bodyweight (r=-0.8, p=.00001). Table 1 shows adiponectin was signficantly associated with dry weight, BP, phosphate, and ADMA (with independent associations of phosphate and ADMA).

Conclusion

Adiponectin was associated with known CV risk factors in a small cohort of HD patients, although phosphate was the only independent predictor. Leptin was associated with anthropometric measurements, consistent with findings from others. The association between phosphate and adiponectin is novel and warrants further investigation.

Table 1:Linear regression (univariate and multivariate) analyses using plasma adiponectin as the outcome
 Univariate Model 1 Model 2 
 Standardized Regression CoefficientP-ValueStandardized Regression Coefficientp-valueStandardized Regression CoefficientP-Value
Phosphate0.40.040.40.020.30.05
ADMA0.40.050.40.020.30.05
Average Systolic BP0.40.040.30.1  
Systolic BP(pre-HD)0.50.020.40.06  
Estimated Dry Weight-0.50.03    

Funding

  • NIDDK Support