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Abstract: TH-PO922

Diet and the Discrepancy Between Cystatin C- and Creatinine-Based eGFR in Middle-Aged and Older Community-Dwelling Japanese Adults

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1500 Health Maintenance, Nutrition, and Metabolism


  • Kabasawa, Keiko, Niigata University, Niigata, Japan
  • Ito, Yumi, Niigata University, Niigata, Japan
  • Kabasawa, Hideyuki, Niigata University, Niigata, Japan
  • Takachi, Ribeka, Nara Women’s University, Nara, Japan
  • Nakamura, Kazutoshi, Niigata University, Niigata, Japan
  • Tanaka, Junta, Niigata University, Niigata, Japan
  • Narita, Ichiei, Niigata University, Niigata, Japan

Discrepancy between creatinine-based eGFR (eGFRcreat) and cystatin C-based eGFR (eGFRcys) is associated with kidney health and frailty. Dietary factors may affect serum creatinine concentration, but little is known about the association between diet and eGFR discrepancy.


Baseline data from a Japanese community-based cohort (age 40–97 years) comprising 3,029 men and 3,115 women were analyzed. We cross-sectionally assessed nutrients and food groups derived from a food frequency questionnaire adjusted by energy intake, using the residual method. eGFR was calculated according to the equation developed for the Japanese population, using creatinine and cystatin C. Discrepancy between eGFRcreat and eGFRcys was assessed as eGFRcys divided by eGFRcreat, with eGFRcys / eGFRcreat > 1.4 used as an outcome variable in this study. The association between diet and eGFR discrepancy was analyzed using logistic regression analysis, with adjustment for potential confounders according to sex.


eGFR discrepancy (eGFRcys / eGFRcreat >1.4) was observed in 9.3% of men and 14.5% of women, with a median eGFRcreat and eGFRcys of 73.9 (interquartile interval: 64.1, 84.7) and 84.7 (72.7, 97.0) in men, and 73.7 (64.8, 83.6) and 87.3 (76.4, 98.6) in women, respectively. In the multivariable logistic regression model, protein, phosphorus, vitamin D, and fish intakes were positively and carbohydrate and grain intakes were negatively associated with eGFR discrepancy in men, while energy, potassium, and phosphorus intakes were positively and carbohydrate and grain intakes were negatively associated with eGFR discrepancy in women (Table).


This study found that some dietary features were associated with the eGFR discrepancy in men and women. The results suggest that not only whole protein intake but also its sources and other dietary features should be taken into account when considering kidney health.


  • Government Support – Non-U.S.