Kidney Week

Abstract: TH-PO922

Diet and the Discrepancy Between Cystatin C- and Creatinine-Based eGFR in Middle-Aged and Older Community-Dwelling Japanese Adults

Session Information

• Health Maintenance, Nutrition, Metabolism - I
  November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1500 Health Maintenance, Nutrition, and Metabolism

Authors

• Kabasawa, Keiko, Niigata University, Niigata, Japan

Keiko Kabasawa,

• Ito, Yumi, Niigata University, Niigata, Japan

Yumi Ito,

• Kabasawa, Hideyuki, Niigata University, Niigata, Japan

Hideyuki Kabasawa,

• Takachi, Ribeka, Nara Women’s University, Nara, Japan

Ribeka Takachi,

• Nakamura, Kazutoshi, Niigata University, Niigata, Japan

Kazutoshi Nakamura,

• Tanaka, Junta, Niigata University, Niigata, Japan

Junta Tanaka,

• Narita, Ichiei, Niigata University, Niigata, Japan

Ichiei Narita,

Background

Discrepancy between creatinine-based eGFR (eGFR_creat) and cystatin C-based eGFR (eGFR_cys) is associated with kidney health and frailty. Dietary factors may affect serum creatinine concentration, but little is known about the association between diet and eGFR discrepancy.

Methods

Baseline data from a Japanese community-based cohort (age 40–97 years) comprising 3,029 men and 3,115 women were analyzed. We cross-sectionally assessed nutrients and food groups derived from a food frequency questionnaire adjusted by energy intake, using the residual method. eGFR was calculated according to the equation developed for the Japanese population, using creatinine and cystatin C. Discrepancy between eGFR_creat and eGFR_cys was assessed as eGFR_cys divided by eGFR_creat, with eGFR_cys / eGFR_creat > 1.4 used as an outcome variable in this study. The association between diet and eGFR discrepancy was analyzed using logistic regression analysis, with adjustment for potential confounders according to sex.

Results

eGFR discrepancy (eGFR_cys / eGFR_creat >1.4) was observed in 9.3% of men and 14.5% of women, with a median eGFR_creat and eGFR_cys of 73.9 (interquartile interval: 64.1, 84.7) and 84.7 (72.7, 97.0) in men, and 73.7 (64.8, 83.6) and 87.3 (76.4, 98.6) in women, respectively. In the multivariable logistic regression model, protein, phosphorus, vitamin D, and fish intakes were positively and carbohydrate and grain intakes were negatively associated with eGFR discrepancy in men, while energy, potassium, and phosphorus intakes were positively and carbohydrate and grain intakes were negatively associated with eGFR discrepancy in women (Table).

Conclusion

This study found that some dietary features were associated with the eGFR discrepancy in men and women. The results suggest that not only whole protein intake but also its sources and other dietary features should be taken into account when considering kidney health.

Funding

• Government Support – Non-U.S.