Abstract: FR-PO418
Psychometric Validation of the CONVINCE Inter- and Intradialytic Symptoms Questionnaire
Session Information
- Hemodialysis: Quality of Life, Symptoms, Palliative Care
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Pham, Le Hong Ngoc, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Hessen, Germany
- Cromm, Krister, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
- Zhang, Yan, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Hessen, Germany
- Schappert, Anna, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
- Liegl, Gregor, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
- Fischer, Kathrin Irmgard, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
- Fischer, Felix, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
- Rose, Matthias, Charite Universitatsmedizin Berlin, Berlin, Berlin, Germany
Group or Team Name
- CONVINCE Scientific Committee and CONVINCE Investigators.
Background
Symptom assessment, especially from the patient perspective, is crucial in dialysis treatment. A comprehensive questionnaire is needed that covers different symptom types. In the CONVINCE study, we developed a survey based on the KDQOL symptoms scale with an adapted recall period of 7 days for interdialytic symptoms and extended inter- and intradialytic (IDS) items based on literature review and patient interviews.
Methods
Patient-reported outcomes data of 1264 hemodialysis patients were extracted from CONVINCE, an international randomized controlled trial comparing high-dose hemodiafiltration with high-flux hemodialysis, including baseline and quarterly follow-up data up to 24 months. The IDS questionnaire consists of 17 items covering interdialytic symptoms (11 based on KDQOL-36) and 5 newly developed items mainly covering intradialytic symptoms. Reliability, item, and validity analyses were conducted to assess the psychometric properties of the questionnaire. Correlations between IDS and Health-Related Quality of Life (HRQL) domains, measured with the PROMIS questionnaires, were calculated.
Results
Reliability analyses showed high internal consistency, stable over time (Cronbach’s α=.86 at baseline, .85-.90 for follow-up visits). Most item-total correlations yielded values from .37-.73, indicating good relationships between individual items and overall score. Item difficulty ranged from .14-.73, revealing a diverse range, ensuring coverage of the symptom spectrum. The survey also showed good validity as correlations between HRQL domains and IDS ranged from .36 to .61. Factor analyses identified 3 symptom clusters (Table 1).
Conclusion
The IDS questionnaire demonstrated good psychometric properties which supports its use in clinical and research settings. By providing a more comprehensive assessment, it is a useful improvement to the KDQOL symptoms scale. Symptoms identified with the questionnaire could be managed in clinical practice and help tailor individualized care.
Funding
- Government Support – Non-U.S.