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Kidney Week

Abstract: TH-PO890

Comorbidity and Multimorbidity Burden in Living Kidney Donors

Session Information

Category: Transplantation

  • 2102 Transplantation: Clinical

Author

  • Lam, Ngan, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
Background

After donation, living donors may develop one or more risk factors that increase the likelihood of subsequent cardiac and kidney adverse events.

Methods

We conducted a cross-sectional, population-based cohort study using linked healthcare databases to study 979 living kidney donors who had donated between 1994 and 2019 in Alberta, Canada. The primary outcome was the presence or history of cardiac and kidney comorbidities, as of March 31, 2020. Cardiac comorbidities included hypertension, diabetes, or major cardiovascular events (myocardial infarction, stroke, or transient ischemic attack). Kidney comorbidities included sustained low eGFR (<45 mL/min/1.73 m2), moderate-severe proteinuria, or kidney stones. Secondary analyses included the presence of other comorbidities, such as cancer, depression, and chronic pain.

Results

The median time since donation was 13 years (IQR 7–19). Of the cardiac comorbidities, hypertension was the most common (31%), followed by diabetes (7%), then major cardiovascular events (5%). Both hypertension and diabetes were present in 5% of donors. For the kidney comorbidities, a history of kidney stones was the most common (12%), while low eGFR (5%) and proteinuria (4%) were uncommon. For the other comorbidities, chronic pain (40%) was most common, followed by depression (36%). Overall, approximately three-quarters of donors had at least 1 comorbidity with the proportion of donors with multimorbidity (≥2 comorbidities) rising with increasing age.

Conclusion

Comorbidity and multimorbidity in the living kidney donor population rises with increasing age. The results of this study may inform long-term follow-up care of donors by identifying those who may benefit most from periodic health reviews.