ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on X

Kidney Week

Abstract: TH-PO305

Volumetric Accuracy Testing (VAT) of a Novel Patient-Centric Gravity-Based Automated Peritoneal Dialysis Cycler (GBC) vs. Conventional Pump-Based Cyclers (PBC)

Session Information

  • Home Dialysis - I
    November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

  • 802 Dialysis: Home Dialysis and Peritoneal Dialysis

Authors

  • Sloand, James A., The George Washington University Milken Institute of Public Health, Washington, District of Columbia, United States
  • Lindo, Steve J., Simergent, Oklahoma City, Oklahoma, United States
  • Pendergraft, Rick, Simergent, Oklahoma City, Oklahoma, United States
Background

Safe and effective APD cycler function requires volumetric accuracy of fill and drain (F/D) volumes to accurately calculate achieved ultrafiltration (UF) critical to clinical outcomes in PD. PD fluid volume measurement in most contemporary APD cyclers is now pump, rather than gravity-based, partly due to unreliability of GBC load cells. However, PBCs contribute to device noise/sleep disruption and drain pain (in up to 47% of patients) from high suction pressures. VAT of a low cost, novel, newly engineered GBC designed to provide reliable F/D volumes was performed and values compared with reported F/D accuracy of conventional PBCs and another recently marketed GBC. In a recent blinded study, features of the novel GBC were rated far more favorably by PD patients & RNs than those of conventional PBCs.

Methods

VAT was performed collecting volume from both a Sartorius laboratory scale (“actual”) and the new GBC (“measured”). VAT was performed on 3 tubing sets with a patient bag at 2 bed heights (36” & 20”) and 2 F/D volumes (500ml & 3000ml). For both Fill & Drain, 5 cycles of 500ml (total 30 F/D cycles) and 3 cycles of 3000ml (total 18 F/D cycles) were tested. VAT was calculated as (measured-actual/actual) x 100%.

Results

Figures 1 & 2 show VAT results for Fill and Drain for 500ml & 3000ml F/D cycles at described bed heights. All 500ml Fills were within the required accuracy bounds of ±2%; all Drains were within the required accuracy bounds of ±3%. VAT for 3000mL volumes for both F/D was within ±1% volumetric error at both bed heights. Published F/D accuracy for FMC Liberty, Baxter HomeChoice, and FMC Silencia (GBC) are ±2%/±3%, ±2/±2%, and <±5%, respectively.

Conclusion

The novel low cost GBC with enhanced load cell technology & features previously demonstrated to be preferred by PD patients & RNs achieved F/D volumetric accuracy comparable to conventional PBCs and better than that of another recently marketed GBC. The new GBC has potential to significantly reduce drain pain, device noise & cost while maintaining UF accuracy.

Funding

  • Commercial Support – Simergent LLC