Kidney Week

Abstract: TH-PO934

Effects of Curcuma longa L. and Green Propolis Extract-Loaded Microcapsules Supplementation on Inflammation in Hemodialysis Patients

Session Information

• Health Maintenance, Nutrition, Metabolism - I
  November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1500 Health Maintenance, Nutrition, and Metabolism

Authors

• Mafra, Denise, Universidade Federal do Rio de Janeiro Centro de Ciencias da Saude, Rio de Janeiro, RJ, Brazil

Denise Mafra,

• Britto, Isadora, Universidade Federal do Rio de Janeiro Centro de Ciencias da Saude, Rio de Janeiro, RJ, Brazil

Isadora Britto,

• Ribeiro, Marcia Maria, Universidade Federal do Rio de Janeiro Centro de Ciencias da Saude, Rio de Janeiro, RJ, Brazil

Marcia Maria Ribeiro,

• de Paiva, Bruna Regis, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil

Bruna Regis de Paiva,

• Brito, Jessyca Sousa de, Universidade Federal do Rio de Janeiro Centro de Ciencias da Saude, Rio de Janeiro, RJ, Brazil

Jessyca Sousa de Brito,

• Teixeira, Karla thais Resende, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil

Karla thais Resende Teixeira,

• Alvarenga, Livia De almeida, Universidade Federal do Rio de Janeiro Centro de Ciencias da Saude, Rio de Janeiro, RJ, Brazil

Livia De almeida Alvarenga,

• Couto, Heloiza, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil

Heloiza Couto,

• Chermut, Tuany Ramos, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil

Tuany Ramos Chermut,

• Delgado, Virgílio Pimentel, Renal Assistencia Medica, Rio de Janeiro, Brazil

Virgílio Pimentel Delgado,

• Cunha, Danielle Figueiredo, Renal Assistencia Medica, Rio de Janeiro, Brazil

Danielle Figueiredo Cunha,

• Ribeiro-Alves, Marcelo, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil

Marcelo Ribeiro-Alves,

• Berretta, Andresa, ApisFlora, Ribeirão Preto, Brazil

Andresa Berretta,

• Cardozo, Ludmila Fmf, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil

Ludmila Fmf Cardozo,

• Leite, Paulo emílio Corrêa, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil

Paulo emílio Corrêa Leite,

Group or Team Name

• Renal Nutrition - UFF.

Background

Nutritional interventions with food that contains bioactive compounds such as Curcuma longa L. and propolis can mitigate inflammation in patients with CKD on hemodialysis (HD). Although broadly available, there are limitations in using these bioactive compounds when ingested in their traditional forms. In this way, the microencapsulation process of these natural compounds can be a good alternative. This longitudinal, double-blind, placebo-controlled study aims to evaluate the effects of Curcuma longa L. and green propolis extract-loaded microcapsules supplementation on inflammatory markers in HD patients.

Methods

Patients were randomized into two groups: Intervention (137mg/d of Curcuma longa L. and 500mg/d of concentrated and standardized green propolis extract EPP-AF®, Apis Flora, Brazil) as microcapsules administrated hard vegetable capsules or placebo for eight weeks. The levels of inflammatory biomarkers (IL-5, GM-CSF, TNF-α, IL-1B, IL-13, IL-4, MCP-1, IL-8, MIP-1, IL-10, G-CSF, IL-7, IL-12 and IL-17) were analyzed by multiplex assay (Bio-Plex Magpix®). C-reactive protein (CRP) was analyzed using a Bioclin device. All analyses were adjusted according to age, sex, BMI and time on HD.

Results

38 patients completed the study; 18 patients in the intervention group (49 ± 18.6 yr.; BMI 21.6 ± 5.2Kg/m²; 8 men) and 20 in the placebo group (49 ± 16.2 yr.; BMI 24.4 ± 3.4Kg/m²; 10 men). After supplementation, MIP-1 and CRP plasma levels were significantly reduced (Fig 1).

Conclusion

Supplementation with 137 mg/d of Curcuma longa L. and 500mg of microencapsulated EPP-AF® green propolis extract in hemodialysis patients for eight weeks significantly reduced MIP-1 and CRP values, evidencing the potential anti-inflammatory effects of the supplement.

Fig 1. There was evidence of reduced plasma levels of MIP-1 (A) and CRP (B) after microcapsules with turmeric and propolis supplementation.

Funding

• Government Support – Non-U.S.