Abstract: TH-PO934
Effects of Curcuma longa L. and Green Propolis Extract-Loaded Microcapsules Supplementation on Inflammation in Hemodialysis Patients
Session Information
- Health Maintenance, Nutrition, Metabolism - I
November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Mafra, Denise, Universidade Federal do Rio de Janeiro Centro de Ciencias da Saude, Rio de Janeiro, RJ, Brazil
- Britto, Isadora, Universidade Federal do Rio de Janeiro Centro de Ciencias da Saude, Rio de Janeiro, RJ, Brazil
- Ribeiro, Marcia Maria, Universidade Federal do Rio de Janeiro Centro de Ciencias da Saude, Rio de Janeiro, RJ, Brazil
- de Paiva, Bruna Regis, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil
- Brito, Jessyca Sousa de, Universidade Federal do Rio de Janeiro Centro de Ciencias da Saude, Rio de Janeiro, RJ, Brazil
- Teixeira, Karla thais Resende, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil
- Alvarenga, Livia De almeida, Universidade Federal do Rio de Janeiro Centro de Ciencias da Saude, Rio de Janeiro, RJ, Brazil
- Couto, Heloiza, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil
- Chermut, Tuany Ramos, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil
- Delgado, Virgílio Pimentel, Renal Assistencia Medica, Rio de Janeiro, Brazil
- Cunha, Danielle Figueiredo, Renal Assistencia Medica, Rio de Janeiro, Brazil
- Ribeiro-Alves, Marcelo, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
- Berretta, Andresa, ApisFlora, Ribeirão Preto, Brazil
- Cardozo, Ludmila Fmf, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil
- Leite, Paulo emílio Corrêa, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil
Group or Team Name
- Renal Nutrition - UFF.
Background
Nutritional interventions with food that contains bioactive compounds such as Curcuma longa L. and propolis can mitigate inflammation in patients with CKD on hemodialysis (HD). Although broadly available, there are limitations in using these bioactive compounds when ingested in their traditional forms. In this way, the microencapsulation process of these natural compounds can be a good alternative. This longitudinal, double-blind, placebo-controlled study aims to evaluate the effects of Curcuma longa L. and green propolis extract-loaded microcapsules supplementation on inflammatory markers in HD patients.
Methods
Patients were randomized into two groups: Intervention (137mg/d of Curcuma longa L. and 500mg/d of concentrated and standardized green propolis extract EPP-AF®, Apis Flora, Brazil) as microcapsules administrated hard vegetable capsules or placebo for eight weeks. The levels of inflammatory biomarkers (IL-5, GM-CSF, TNF-α, IL-1B, IL-13, IL-4, MCP-1, IL-8, MIP-1, IL-10, G-CSF, IL-7, IL-12 and IL-17) were analyzed by multiplex assay (Bio-Plex Magpix®). C-reactive protein (CRP) was analyzed using a Bioclin device. All analyses were adjusted according to age, sex, BMI and time on HD.
Results
38 patients completed the study; 18 patients in the intervention group (49 ± 18.6 yr.; BMI 21.6 ± 5.2Kg/m2; 8 men) and 20 in the placebo group (49 ± 16.2 yr.; BMI 24.4 ± 3.4Kg/m2; 10 men). After supplementation, MIP-1 and CRP plasma levels were significantly reduced (Fig 1).
Conclusion
Supplementation with 137 mg/d of Curcuma longa L. and 500mg of microencapsulated EPP-AF® green propolis extract in hemodialysis patients for eight weeks significantly reduced MIP-1 and CRP values, evidencing the potential anti-inflammatory effects of the supplement.
Fig 1. There was evidence of reduced plasma levels of MIP-1 (A) and CRP (B) after microcapsules with turmeric and propolis supplementation.
Funding
- Government Support – Non-U.S.