Kidney Week

Abstract: FR-PO929

Circulating Proteins Associated with Mortality in Patients with CKD

Session Information

• CKD Epidemiology, Risk Factors, Prevention - II
  November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Srialluri, Nityasree, Johns Hopkins Medicine, Baltimore, Maryland, United States

Nityasree Srialluri,

• Surapaneni, Aditya L., New York University Grossman School of Medicine, New York, New York, United States

Aditya L. Surapaneni,

• Schlosser, Pascal, Johns Hopkins University Welch Center for Prevention Epidemiology and Clinical Research, Baltimore, Maryland, United States

Pascal Schlosser,

• Chen, Teresa K., University of California San Francisco School of Medicine, San Francisco, California, United States

Teresa K. Chen,

• Schmidt, Insa Marie, Boston Medical Center, Boston, Massachusetts, United States

Insa Marie Schmidt,

• Rhee, Eugene P., Massachusetts General Hospital, Boston, Massachusetts, United States

Eugene P. Rhee,

• Coresh, Josef, Johns Hopkins University Welch Center for Prevention Epidemiology and Clinical Research, Baltimore, Maryland, United States

Josef Coresh,

• Grams, Morgan, New York University Grossman School of Medicine, New York, New York, United States

Morgan Grams,

Background

Proteomics could provide pathophysiologic insight into the increased risk of mortality in patients with chronic kidney disease (CKD). This study aimed to investigate associations between the circulating proteome and all-cause mortality among patients with CKD.

Methods

In this observational cohort study, we quantified the associations of 6790 circulating proteins with the outcome of all-cause mortality among 703 participants in the African American Study of Kidney Disease (AASK) Study. Proteins with significant associations were further evaluated among Atherosclerosis Risk in Communities (ARIC) Study participants with chronic kidney disease (Visit 5; N = 1628).

Results

In the AASK cohort, mean age was 54.5 years, 271 (38.5%) were women and mean measured GFR was 46 ml/min per 1.73m². Median follow up was 9.6 years and 7 distinct proteins (Lamin-B2, Spondin-1, Somatostatin receptor type 1, N-terminal pro-BNP, DDRGK domain-containing protein 1, Beta-2-microglobulin, and N6-adenosine-methyltransferase 70kDa subunit) were associated with all-cause mortality at Bonferroni-level threshold (p<0.05/6790) after adjustment for demographics and clinical factors, including baseline measured eGFR and proteinuria. In ARIC visit 5 cohort, mean age was 77.2 years, 903 (55.5%) were women, mean estimated GFR was 54 ml/min per 1.73m² and median follow up was 6.9 years. Of the seven proteins found in AASK, three (Beta-2-microglobulin, Spondin-1, and N-terminal pro-BNP) were available in the ARIC data, with all three significantly associated with death in ARIC.

Conclusion

Using large-scale proteomic analysis, known and novel proteins were reproducibly associated with mortality in two cohorts of participants with CKD.

Funding

• NIDDK Support