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Abstract: SA-PO723

Prevalence of Hyponatremia in Dengue-Infected Patients: Relationship with Systemic Inflammation

Session Information

Category: Fluid, Electrolytes, and Acid-Base Disorders

  • 1102 Fluid, Electrolyte, and Acid-Base Disorders: Clinical

Authors

  • Ayus, Juan Carlos, University of California Irvine, Irvine, California, United States
  • Lee, Kyung Min, Hospital Nacional Profesor Alejandro Posadas, El Palomar, Buenos Aires, Argentina
  • Caputo, Daniel, Hospital Nacional Profesor Alejandro Posadas, El Palomar, Buenos Aires, Argentina
  • Negri, Armando, Universidad del Salvador Facultad de Medicina, Buenos Aires, Buenos Aires, Argentina
  • Eghi, Carlos, Hospital Nacional Profesor Alejandro Posadas, El Palomar, Buenos Aires, Argentina
Background

Dengue infection is becoming more prevalent worldwide and is associated with systemic inflammation. Systemic Inflammation is associated with non-osmotic release of ADH.
Purpose: To evaluate the prevalence of hyponatremia in newly infected patients and its relationship with systemic inflammation.

Methods

Cross-sectional study in 375 patients with newly diagnosed dengue infection at Hospital Posadas in Argentina. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration <135 mEq/L.

Results

Hyponatremia was present in 30.13% of the patients at admission. In multivariate logistic regression model, the OR for hyponatremia adjusting for age and sex was significant in the patients over 65 years, OR 6.034 (IC95 2.652-13.728) p= 0.001. We also analyzed the relationship of hyponatremia with C-reactive Protein (CRP). In multivariate logistic regression model adjusted for age, sex and CRP, OR for hyponatremia was significant in the group of patients with elevated CRP, OR 3.37 (IC95 1.439-7.895) p= 0.005. We found a negative correlation between serum sodium and CRP (Spearman correlation coefficient rho= - 0.283; p=0.002).

Conclusion

1: The prevalence of hyponatremia is high in newly infected patients with dengue; 2: Degree of hyponatremia correlated with severity of inflammation.