Abstract: FR-PO897
A Pragmatic Randomized Clinical Trial: Twice-Weekly vs. Thrice-Weekly Incident Hemodialysis in Elderly Patients (PRIDE): Study Protocol
Session Information
- Geriatric Nephrology
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Geriatric Nephrology
- 1300 Geriatric Nephrology
Authors
- Han, Miyeun, National Medical Center, Seoul, Korea (the Republic of)
- Song, Sang Heon, Pusan National University, Kumjeong-ku, Korea (the Republic of)
- Kwon, Soon hyo, Soonchunhyang University Hospital, Seoul, Korea (the Republic of)
Background
The optimal frequency for hemodialysis in older adults with end-stage kidney disease (ESKD) has not been established. This study aims to investigate whether a twice-weekly dialysis schedule using an incremental approach can reduce hospitalization rates in older adults with incident dialysis, compared with conventional thrice-weekly dialysis in South Korea.
Methods
We have designed a pragmatic randomized controlled trial to compare the effects of twice-weekly versus thrice-weekly hemodialysis in 428 ESKD (drop-out rate 20%) individuals aged 60 years or older with residual kidney function (urine output > 500 mL/day). The trial will be conducted across 18 referral hospital-based dialysis centers in Korea. Individual participants will be randomized to either the twice-weekly (with incremental approach) or thrice-weekly dialysis group and will be followed up for 24 months. The primary outcome of the study is the difference in all-cause hospitalization rates, while secondary outcomes include dialysis-specific hospitalization rates, mortality, quality of life, frailty, and cost-effectiveness. Participants have the flexibility to transfer to other dialysis centers as needed. The decision to increase dialysis frequency will be made by the treating physicians.
Results
The study is ongoing and will be completed in May 2026.
Conclusion
This study will provide valuable insights into the benefits and risks of twice-weekly dialysis with an incremental approach in older adults with residual kidney function compared to conventional dialysis treatment.
Funding
- Government Support – Non-U.S.