ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on X

Kidney Week

Please note that you are viewing an archived section from 2023 and some content may be unavailable. To unlock all content for 2023, please visit the archives.

Abstract: FR-PO897

A Pragmatic Randomized Clinical Trial: Twice-Weekly vs. Thrice-Weekly Incident Hemodialysis in Elderly Patients (PRIDE): Study Protocol

Session Information

  • Geriatric Nephrology
    November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Geriatric Nephrology

  • 1300 Geriatric Nephrology


  • Han, Miyeun, National Medical Center, Seoul, Korea (the Republic of)
  • Song, Sang Heon, Pusan National University, Kumjeong-ku, Korea (the Republic of)
  • Kwon, Soon hyo, Soonchunhyang University Hospital, Seoul, Korea (the Republic of)

The optimal frequency for hemodialysis in older adults with end-stage kidney disease (ESKD) has not been established. This study aims to investigate whether a twice-weekly dialysis schedule using an incremental approach can reduce hospitalization rates in older adults with incident dialysis, compared with conventional thrice-weekly dialysis in South Korea.


We have designed a pragmatic randomized controlled trial to compare the effects of twice-weekly versus thrice-weekly hemodialysis in 428 ESKD (drop-out rate 20%) individuals aged 60 years or older with residual kidney function (urine output > 500 mL/day). The trial will be conducted across 18 referral hospital-based dialysis centers in Korea. Individual participants will be randomized to either the twice-weekly (with incremental approach) or thrice-weekly dialysis group and will be followed up for 24 months. The primary outcome of the study is the difference in all-cause hospitalization rates, while secondary outcomes include dialysis-specific hospitalization rates, mortality, quality of life, frailty, and cost-effectiveness. Participants have the flexibility to transfer to other dialysis centers as needed. The decision to increase dialysis frequency will be made by the treating physicians.


The study is ongoing and will be completed in May 2026.


This study will provide valuable insights into the benefits and risks of twice-weekly dialysis with an incremental approach in older adults with residual kidney function compared to conventional dialysis treatment.


  • Government Support – Non-U.S.