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Kidney Week

Abstract: TH-PO175

Global Proteomic Search for Circulating Proteins Associated with Albuminuria in Patients with Diabetic Kidney Disease

Session Information

Category: Diabetic Kidney Disease

  • 702 Diabetic Kidney Disease: Clinical

Authors

  • Tye, Sok Cin, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Looker, Helen C., Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, United States
  • Md Dom, Zaipul, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Satake, Eiichiro, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Ricca, Joseph, Joslin Diabetes Center, Boston, Massachusetts, United States
  • Nelson, Robert G., Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, United States
  • Krolewski, Andrzej S., Joslin Diabetes Center, Boston, Massachusetts, United States

Group or Team Name

  • Section of Genetics and Epidemiology, Joslin Diabetes Center.
Background

Fast kidney function decline and the presence of albuminuria are traditional predictors of progression to end-stage kidney disease (ESKD) in patients with diabetic kidney disease (DKD). In this study, we aim to identify circulating proteins associated with albuminuria in patients with DKD and to compare them with 46 novel proteins associated with fast kidney function decline previously reported by us [1].

Methods

Using the SOMAscan proteomics platform, we measured the baseline concentration of 550 circulating proteins in participants with type 1 diabetes from the Joslin Kidney Cohort (JKC, N=294), and with type 2 diabetes from the Pima Indian cohort (N=162). Spearman rank correlation was used in an untargeted analysis to assess the association between measured proteins and albuminuria in both cohorts. We used a Venn diagram to describe proteins contributing to the development of albuminuria and/or ESKD.

Results

In the JKC and Pima Indian cohorts, 196 proteins (P<0.00001) and 55 proteins (P<0.001), respectively, were associated with albuminuria; 31 of them were common to both cohorts. Comparing these 31 proteins to the 46 proteins associated with the risk of progression to ESKD, we identified 13 proteins associated with both outcomes (Figure 1).

Conclusion

Our findings indicate that the underlying disease processes for albuminuria and progressive kidney function decline are very different. Only a few circulating proteins are common indicators for both processes.

References: 1. Kobayashi, H., et al., Results of untargeted analysis using the SOMAscan proteomics platform indicates novel associations of circulating proteins with risk of progression to kidney failure in diabetes. Kidney Int, 2022. 102(2): p. 370-381.