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Kidney Week

Abstract: TH-PO892

Changes in Sex Lives Pre- and Post-Kidney Transplantation

Session Information

Category: Transplantation

  • 2102 Transplantation: Clinical

Authors

  • Gupta, Natasha, New York University Grossman School of Medicine, New York, New York, United States
  • Liu, Yi, New York University Grossman School of Medicine, New York, New York, United States
  • McAdams-DeMarco, Mara, New York University Grossman School of Medicine, New York, New York, United States
Background

Sexual dysfunction among patients with kidney disease (KD) is common. Although studies have demonstrated improvements in sexual function after kidney transplantation (KT), the impact of KD on patients’ sex lives pre- and post-KT is unknown.

Methods

We leveraged a prospective cohort of 497 adult KT recipients who responded to the Kidney Disease Quality of Life questionnaire from 2014 to 2022 at Johns Hopkins. Adjusted logistic regression models were used to estimate characteristics associated with self-reported sexual bother due to KD pre-KT, and sexual bother pre- and 3 years post-KT was compared using a Chi-squared test. We estimated unadjusted trajectories of the prevalence of sexual bother due to KD pre- and post-KT using mixed-effect logistic models. We also assessed the prevalence of sexual activity pre- and 3 years post-KT.

Results

The mean age was 52.2 + 13.5 years, 37.0% were female, 43.1% were Black, 59.6% were partnered, and 41.6% were prior or current smokers. Overall, 43.5% (26.6% of females and 53.4% of males) had sexual bother due to KD pre-KT versus 22.8% (14.8% of females and 26.9% of males) 3 years post-KT (p=0.001). Pre-KT, participants who were male (adjusted odds ratio [aOR]=3.08 [95%CI:2.02-4.69]), non-Black (aOR=1.65 [95% CI:1.09-2.51]), partnered (aOR=1.93 [95% CI:1.27-2.93]), or prior or current smokers (aOR=1.65 [95% CI: 1.10-2.47]) had significantly more sexual bother. Estimated sexual bother due to KD improved significantly over time across all subgroups (Table 1). Overall self-reported sexual activity within the past month also increased significantly from 39.9% pre-KT to 44.0% 3 years post-KT (p=0.009). Both male and female participants had similar increases in sexual activity from pre- to 3 years post-KT (males: 39.6% to 44.0%, p=0.045; females: 40.3% to 44.0%, p=0.178), though the increase was only statistically significant among male participants.

Conclusion

Sexual bother due to KD is common and improves significantly after KT for patients across varying subgroups. The impact of KD on patients’ sex lives can be mitigated by KT.

Funding

  • Other NIH Support