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Kidney Week

Abstract: SA-PO1094

The Association Between Higher Serum Triglyceride Level and Poor Kidney Outcome Among Patients with CKD: The Fukuoka Kidney Disease Registry (FKR) Study

Session Information

Category: CKD (Non-Dialysis)

  • 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Seki, Mai, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Nakano, Toshiaki, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Tanaka, Shigeru, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Kitamura, Hiromasa, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Hiyamuta, Hiroto, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Tsuruya, Kazuhiko, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Kitazono, Takanari, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
Background

Dyslipidemia, especially hypertriglyceridemia, is a very common complication in patients with chronic kidney disease (CKD). Although hypertriglyceridemia is known to be a risk factor for the development of CKD in the general population, it is unclear whether there is a relationship between higher serum triglyceride levels and the progression of kidney failure in patients with CKD. The aim of this study was to investigate the relationship between serum triglyceride levels and the progression of kidney failure.

Methods

A total of 4,101 Japanese outpatients aged ≥16 years were prospectively followed for 5 years. Patients were divided into four groups based on quartiles of serum triglyceride levels at baseline (<87, 87-120, 121-170, >170 mg/dL). The primary outcome was the progression of kidney failure, defined by a 1.5-fold increase in serum creatinine from baseline or the development of end-stage kidney disease. We estimated the relationship between serum triglyceride and the outcome using a multivariable-adjusted Cox proportional hazards model.

Results

During the 5-year observation period, 1410 patients developed the progression of kidney failure. The incidence rate of the progression of kidney failure increased linearly with the increase in serum triglyceride levels (P for trend <0.05). In the multivariable-adjusted analysis, the hazard ratio (HR) for the progression of kidney failure in the highest serum triglyceride quartile (Q4) was 1.22 (95% CI, 1.02-1.45; P <0.05) compared with the lowest serum triglyceride quartile (Q1). This association was increased in patients with higher baseline BMI (≥ 25 kg/m2) (P for heterogeneity <0.05).

Conclusion

The current study shows that higher serum triglyceride level is associated with the progression of kidney failure in patients with CKD. It also highlighted that this relationship was more pronounced in individuals with a higher BMI.