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Kidney Week

Abstract: SA-PO121

Exploring Lipid Biomarkers of Cardiac Surgery-Associated AKI Based on Lipidomics

Session Information

Category: Acute Kidney Injury

  • 102 AKI: Clinical, Outcomes, and Trials

Authors

  • Xu, Youjun, Ningbo No. 2 Hospital, Ningbo, China
  • Zhou, Fangfang, Ningbo No. 2 Hospital, Ningbo, China
  • Wang, Lailiang, Ningbo No. 2 Hospital, Ningbo, China
  • Zhang, Shuzhen, Ningbo No. 2 Hospital, Ningbo, China
  • Zheng, Xingyue, Ningbo No. 2 Hospital, Ningbo, China
  • Luo, Qun, Ningbo No. 2 Hospital, Ningbo, China
Background

Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequently occurring complication. Lipids played important roles in many biological pathways and could work as biomarkers of disease. The purpose of this study was to explore lipid biomarkers of CSA-AKI.

Methods

Plasma samples were collected when patients admitted to the ICU after cardiac surgery from 24 CSA-AKI patients and 31 controls. Lipidomic approach based on liquid chromatography mass spectrometer (LC-MS) was used to analyze plasma lipidomic alterations and potential biomarkers for CSA-AKI patients. Univariate and multivariate statistical analyses were utilized to screen the differential lipids between two groups.

Results

Lipidomics analysis detected 4053 lipid species totally. Differentially expressed lipids were screened based on the criteria variable importance at projection (VIP) value > 1, p value < 0.05, and fold change (FC) > 1.5 or < 0.67. Lipidomics identified that 65 lipids satisfied the criteria. The volcano plot showed the results of differential expression of lipids (figure 1). Heat map presented the relative levels of lipids (figure 2).

Conclusion

Lipidomics profiles could change significantly in CSA-AKI patients, and some lipid species were notably upregulated in the early stage of CSA-AKI, which could serve as potential biomarkers for CSA-AKI.

Figure 1. volcano spot

Figure 2. heat map