Kidney Week

Abstract: TH-PO851

Prevalence and Correlated Factors of Vascular Calcification and Vascular Stiffness in Kidney Transplant Patients

Session Information

• Transplantation: Clinical - I
  November 02, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 2102 Transplantation: Clinical

Authors

• Chongvoranond, Peachaphol, King Chulalongkorn Memorial Hospital, Bangkok, Bangkok, Thailand

Peachaphol Chongvoranond,

• Tumkosit, Monravee, King Chulalongkorn Memorial Hospital, Bangkok, Bangkok, Thailand

Monravee Tumkosit,

• Phannajit, Jeerath, King Chulalongkorn Memorial Hospital, Bangkok, Bangkok, Thailand

Jeerath Phannajit,

• Townamchai, Natavudh, King Chulalongkorn Memorial Hospital, Bangkok, Bangkok, Thailand

Natavudh Townamchai,

• Eiam-Ong, Somchai, King Chulalongkorn Memorial Hospital, Bangkok, Bangkok, Thailand

Somchai Eiam-Ong,

• Praditpornsilpa, Kearkiat, King Chulalongkorn Memorial Hospital, Bangkok, Bangkok, Thailand

Kearkiat Praditpornsilpa,

• Avihingsanon, Yingyos, King Chulalongkorn Memorial Hospital, Bangkok, Bangkok, Thailand

Yingyos Avihingsanon,

• Susantitaphong, Paweena, King Chulalongkorn Memorial Hospital, Bangkok, Bangkok, Thailand

Paweena Susantitaphong,

Background

Mineral and bone disorders related with chronic kidney disease (CKD) increased risk of vascular health in both CKD and dialysis patients, leading causes of morbidity and mortality. Although, kidney transplantation (KT) is the best way to treat end stage kidney disease and some important risk factors might be improved after KT, the prevalence of vascular diseases seems to be persistently high in KT recipients. Early detection, prevention and optimal management is the key to attenuate vascular diseases in KT.

Methods

This cross-sectional study was conducted in 400 KT recipients who received KT for at least 1 year and followed up at King Chulalongkorn Memorial Hospital. Plain film of lateral abdomen was done to assess the presence of vascular calcification (Abdominal aortic calcification scores) while cardio-ankle vascular index was performed to evaluate vascular stiffness. Severe vascular calcification was defined by using abdominal aortic calcification scores ≥ 5.5. Baseline characteristics, laboratory data, and medications were collected for evaluation of important risk factors by multivariable logistic regression analysis.

Results

400 KT recipients were enrolled in this study. The prevalence of severe vascular calcification and vascular stiffness were 35.94% and 27.75%, respectively. By multivariable logistic regression, diabetes mellitus and post parathyroidectomy were correlated with severe vascular calcification (OR 2.299; 95%CI 1.036-5.100, OR 7.668; 95%CI 2.928- 20.082, respectively). Systolic blood pressure, mean arterial pressure and severe vascular calcification were related with vascular stiffness (OR 0.960; 95%CI 0.928-0.992, OR 1.085; 95%CI 1.038-1.133, OR 2.256; 95%CI 1.223-4.162, respectively) while elderly was correlated both severe vascular calcification and vascular stiffness (OR 1.108; 95%CI 1.074-1.142, OR 1.094; 95%CI 1.057-1.133, respectively).

Conclusion

The prevalence of vascular calcification and vascular stiffness were still high in KT recipients. Optimal management of important risk factors including mineral bone disorders (CKD-MBD) before and after KT, diabetes and blood pressure control should be highlighted to attenuate cardiovascular diseases in KT recipients.

Funding

• Private Foundation Support