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Abstract: FR-PO101

Analysis of Influencing Factors of Poor Prognosis in Patients with Acute Respiratory Distress Syndrome Complicated with AKI

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

  • Gu, Yue, Henan Provincial People's Hospital, Zhengzhou, Henan, China
  • Zhou, Jing, Henan Provincial People's Hospital, Zhengzhou, Henan, China
  • Jia, Shen Yi, Henan Provincial People's Hospital, Zhengzhou, Henan, China
  • Shao, Fengmin, Henan Provincial People's Hospital, Zhengzhou, Henan, China
Background

To study the influencing factors of poor prognosis in patients with acute respiratory distress syndrome (ARDS) complicated with acute kidney injury (AKI) in ICU.

Methods

Retrospective analysis was performed on patients with ARDS complicated with AKI admitted to the ICU. The stage of AKI was determined according to the change of blood creatinine value within 7 days after the diagnosis of AKI. They were divided into 28-day survival group (28-S) and 28-day death group (28-D) according to their survivalist 28 days. Multivariate COX regression analysis was used to analysis of influencing factors of 28-day death in patients with ARDS complicated with AKI.

Results

265 patients with ARDS complicated with AKI has a median age of 68 (54,75) years old. 154 patients died within 28 days(58.1%). Compared to the 28-S group, age, proportion of renal function early unrecovered, proportion of combined coronary heart disease, proportion of combined malignant tumor, acute physiology and chronic health evaluation scoring system II, proportion of pulmonary ARDS, proportion of positive fluid balance accumulated on day 2 of ICU admission, proportion of severe AKI, blood lactic acid of the 28-D group were higher (P<0.05). The arterial partial pressure of oxygen, arterial oxygen saturation, oxygenation idex of the 28-D group were lower (P<0.05). Multivariate COX regression analysis showed that renal function early unrecovered (HR=1.936, 95%CI 1.238~3.027, P=0.004), combined malignant tumor (HR=1.983, 95%CI 1.301~3.023, P=0.001), positive fluid balance accumulated on day 2 of ICU admission (HR=1.428, 95%CI 1.013~2.015, P=0.042), oxygenation index(HR=0.647, 95%CI 0.447~0.937, P=0.021) were independent influencing factors for the 28-day death in patients with ARDS complicated with AKI.

Conclusion

Renal function early unrecovered, combined malignant tumor, positive fluid balance accumulated on day 2 of ICU admission, oxygenation index decreased are associated with poor prognosis in patients with ARDS complicated with AKI.

Influencing factors of 28-day death in ARDS patients complicated with AKI
FactorsMultivariate COX regression analysis
P-valueHR95%CI
Renal Function Early Unrecovered(Yes/No)0.0041.9361.238~3.027
Combined Malignant Tumor(Yes/No)0.0011.9831.301~3.023
Positive Fluid Balance Accumulated on Day 2 of Icu Admission(Yes/No)0.0421.4281.013~2.015
Oxygenation Index(Every 1mmHg increase)0.0210.6470.447~0.937

Funding

  • Government Support – Non-U.S.