Abstract: FR-PO956
Appraisal of a Simplified Protein Energy Wasting Score in CKD Patients at a Single University-Based Hospital: A Five-Year Retrospective Cohort Study
Session Information
- CKD Epidemiology, Risk Factors, Prevention - II
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Rattanasompattikul, Manoch, Golden Jubilee Medical Center, Nakorn Pathom, Thailand
- Phicheansoonthorn, Jadenapa, Golden Jubilee Medical Center, Nakorn Pathom, Thailand
- Rongkiettechakorn, Nuttawut, Golden Jubilee Medical Center, Nakorn Pathom, Thailand
- Jampong, Malinporn, Golden Jubilee Medical Center, Nakorn Pathom, Thailand
- Promkan, Moltira, Mahidol University Faculty of Medical Technology Bangkok Noi Campus, Bangkok, Bangkok, Thailand
Background
Undernutrition poses a significant complication of chronic kidney disease (CKD), leading to devastating effects on quality of life, morbidity, hospitalization, and mortality. We developed a novel Protein Energy Wasting (PEW) score, utilizing the nomenclature proposed by the International Society of Renal Nutrition and Metabolism in 2008.
Methods
We enrolled participants aged 18 years or older, with CKD stages G3 to G5ND between January 2016 and December 2020. These were utilized for diagnosing PEW using the simplified PEW score (sPEW). The sPEW was defined by the following criteria (Figure 1), and the Lean Body Mass Index (LBMI = LBM/height2) was subsequently determined.
Results
In total, 224 patients were identified (64% male, 36% female; mean age 77 years), with the majority classified as stages 3a, 3b, and 4 CKD (41%, 38%, and 18%, respectively). The prevalence, according to the sPEW score, showed 85 (38%) with mild PEW, 26 (12%) with moderate PEW, and four (2%) with severe PEW. LBMI was 17.3 ± 22.4, 15.7 ± 1.9, 15.5 ± 2.1, and 13.5 ± 0.5 kg/m2 in the none, mild, moderate, and severe sPEW groups, respectively (P<0.001). The multiple linear regression analysis indicated that changes in lean body mass index negatively correlated with changes in the sPEW score and gender (P<0.001) (Figure 2).
Conclusion
These studies suggest that the sPEW, when used in CKD patients, appears to reflect the LBMI in these populations. Further research is required to determine the validity of the sPEW as a nutritional marker and to explore its predictive value for other clinical outcomes in CKD patients.
Figure1
Figure2